Reference : Nitroglycerin sensitises in healthy subjects CNS structures involved in migraine path...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/23516
Nitroglycerin sensitises in healthy subjects CNS structures involved in migraine pathophysiology: evidence from a study of nociceptive blink reflexes and visual evoked potentials.
English
Di Clemente, Laura [> > > >]
Coppola, Gianluca [> > > >]
Magis, Delphine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Gérardy, Pierre-Yves [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Fumal, Arnaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
De Pasqua, Victor [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Di Piero, Vittorio [> > > >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
2009
Pain
Elsevier Science
144
1-2
156-61
Yes (verified by ORBi)
International
0304-3959
1872-6623
Amsterdam
The Netherlands
[en] Adult ; Analysis of Variance ; Blinking/drug effects ; Dose-Response Relationship, Drug ; Drug Administration Routes ; Electric Stimulation/adverse effects ; Electroencephalography/methods ; Evoked Potentials, Visual/drug effects ; Female ; Habituation, Psychophysiologic/drug effects ; Humans ; Male ; Migraine Disorders/chemically induced/physiopathology ; Nitric Oxide Donors/adverse effects/pharmacology ; Nitroglycerin/adverse effects/pharmacology ; Pain/etiology/physiopathology ; Pain Threshold/drug effects ; Young Adult
[en] Nitroglycerin (NTG), a NO donor, induces an attack in migraine patients approximately 4-6 h after administration. The causative mechanisms are not known, but the long delay leaves room for a central effect, such as a change in neuronal excitability and synaptic transmission of various CNS areas involved in pain and behaviour including trigeminal nucleus caudalis and monoaminergic brain stem nuclei. To explore the central action of NTG, we have studied its effects on amplitude and habituation of the nociceptive blink reflex (nBR) and the visual evoked potential (VEP) before, 1 h and 4 h after administration of NTG (1.2 mg sublingual) or placebo (vehicle sublingual) in two groups of 10 healthy volunteers. We found a significant decrease in nBR pain and reflex thresholds both 1 and 4 h post-NTG. At the 4 h time point R2 latency was shorter (p=0.04) and R2 response area increased (p<0.01) after NTG but not after placebo. Habituation tended to become more pronounced after both NTG and placebo administration. There was a significant amplitude increase in the 5th VEP block (p=0.03) at 1h after NTG and in the 1st block (p=0.04) at 4 h. VEP habituation was replaced by potentiation at both delays after NTG; the change in habituation slope was significant at 1h (p=0.02). There were no significant VEP changes in subjects who received sublingual placebo. In conclusion, we found that in healthy subjects sublingual NTG, but not its vehicle, induces changes in a trigeminal nociceptive reflex and an evoked cortical response which are comparable to those found immediately before and during an attack of migraine. These changes could be relevant for the attack-triggering effect of NTG in migraineurs.
http://hdl.handle.net/2268/23516
10.1016/j.pain.2009.04.018

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