Reference : High-level biosynthesis of the anteiso-C(17) isoform of the antibiotic mycosubtilin in B...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/23494
High-level biosynthesis of the anteiso-C(17) isoform of the antibiotic mycosubtilin in Bacillus subtilis and characterization of its candidacidal activity.
English
Fickers, Patrick mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Guez, Jean-Sebastien [> > > >]
Damblon, Christian mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie biologique structurale >]
Leclere, Valerie [> > > >]
Bechet, Max [> > > >]
Jacques, Philippe [> > > >]
Joris, Bernard mailto [Université de Liège - ULg > Département des sciences de la vie > Physiologie et génétique bactériennes - Centre d'ingénierie des protéines >]
2009
Applied and Environmental Microbiology
American Society for Microbiology (ASM)
75
13
4636-40
Yes (verified by ORBi)
International
0099-2240
1098-5336
Washington
DC
[en] Antibiotics, Antifungal/biosynthesis ; Bacillus subtilis/genetics/metabolism ; Biosynthetic Pathways/genetics ; Candida/drug effects ; Genes, Bacterial ; Genetic Engineering ; Lipoproteins/biosynthesis ; Microbial Sensitivity Tests ; Protein Isoforms/metabolism
[en] High-level production (880 mg liter(-1)) and isolation of the anteiso-C(17) isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp.
http://hdl.handle.net/2268/23494
10.1128/AEM.00548-09

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