Article (Scientific journals)
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.
Jousset, C.; Carron, C.; Boureux, A. et al.
1997In EMBO Journal
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Keywords :
leukemia; chromosomal translocation; ETS transcription factors
Abstract :
[en] TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino-terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Jousset, C.;  Institut Curie (France) > CNRS UMR 146
Carron, C.;  Institut Curie (France) > CNRS UMR 146
Boureux, A.;  Institut Curie (France) > CNRS UMR 146
Quang, C. T.;  Institut Curie (France) > CNRS UMR 146
Oury, Cécile  ;  Institut Curie (France) > CNRS UMR 146
Dusanter-Fourt, I.;  Institut Cochin de Génétique Moléculaire > INSERM U 363
Charon, M.;  Institut Cochin de Génétique Moléculaire > INSERM U 363
Levin, J.;  Institut National de la Recherche Agronomique (France)
Bernard, Olivier A;  Institut de Génétique Moléculaire (France) > INSERM U 301
Ghysdael, Jacques;  Institut Curie (France) > CNRS UMR 146
Language :
English
Title :
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.
Publication date :
1997
Journal title :
EMBO Journal
ISSN :
0261-4189
eISSN :
1460-2075
Publisher :
Oxford University Press, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 September 2009

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