ORBi: Jousset C. - A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.

Reference : A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/23469

Title :	A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.
Language :	English
Author, co-author :	Jousset, C. [Institut Curie (France) > > CNRS UMR 146 > >]
	Carron, C. [Institut Curie (France) > > CNRS UMR 146 > >]
	Boureux, A. [Institut Curie (France) > > CNRS UMR 146 > >]
	Quang, C. T. [Institut Curie (France) > > CNRS UMR 146 > >]
	Oury, Cécile [Institut Curie (France) > > CNRS UMR 146 > >]
	Dusanter-Fourt, I. [Institut Cochin de Génétique Moléculaire > > INSERM U 363 > >]
	Charon, M. [Institut Cochin de Génétique Moléculaire > > INSERM U 363 > >]
	Levin, J. [Institut National de la Recherche Agronomique (France) > > > >]
	Bernard, Olivier A [Institut de Génétique Moléculaire (France) > > INSERM U 301 > >]
	Ghysdael, Jacques [Institut Curie (France) > > CNRS UMR 146 > >]
Publication date :	1997
Journal title :	EMBO Journal
Publisher :	Oxford University Press
Audience :	International
ISSN :	0261-4189
e-ISSN :	1460-2075
City :	Oxford
Country :	United Kingdom
Keywords :	[en] leukemia ; chromosomal translocation ; ETS transcription factors
Abstract :	[en] TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino-terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators.
Permalink :	http://hdl.handle.net/2268/23469

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