TEL is a sequence-specific transcriptional repressor.

[en] TEL is a gene frequently involved in specific chromosomal translocations in human leukemia and sarcoma that encodes a member of the ETS family of transcriptional regulators. TEL is unusual among other ETS proteins by its ability to self-associate in vivo, a property that is essential to the oncogenic activation of TEL-derived fusion proteins. We show here that TEL is a sequence-specific transcriptional repressor of ETS-binding site-driven transcription of model and natural promoters.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Lopez, Rodolphe; Institut Curie (France) > CNRS UMR 146

Carron, Clémence; Institut Curie (France) > CNRS UMR 146

Oury, Cécile ; Institut Curie (France) > CNRS UMR 146

Gardellin, P.; CEPH (France) > Inserm U434

Bernard, Olivier; CEPH (France) > INSERM U434

Ghysdael, Jacques; Institut Curie (France) > CNRS UMR 146

Language :

English

Title :

TEL is a sequence-specific transcriptional repressor.

Publication date :

1999

Journal title :

Journal of Biological Chemistry

ISSN :

0021-9258

eISSN :

1083-351X

Publisher :

American Society for Biochemistry and Molecular Biology, Baltimore, United States - Maryland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 September 2009

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