Article (Scientific journals)
P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen.
Oury, Cécile; Toth-Zsamboki, Emese; Vermylen, Jos et al.
2002In Blood
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Keywords :
platelets; signaling; purinergic receptors
Abstract :
[en] This study shows that mild platelet stimulation with collagen rapidly releases ATP, which activates the P2X(1)-PKC-ERK2 pathway. This process enhances further degranulation of the collagen-primed granules allowing platelet aggregation to be completed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Oury, Cécile  ;  Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB
Toth-Zsamboki, Emese;  Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB
Vermylen, Jos;  Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB
Hoylaerts, Marc F;  Katholieke Universiteit Leuven - KUL > Molecular and Cellular Medicine > CMVB
Language :
English
Title :
P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen.
Publication date :
2002
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 September 2009

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