ORBi: Geenen Vincent - Cellular and molecular aspects of thymic T-cell education to neurohypophysial peptides

Reference : Cellular and molecular aspects of thymic T-cell education to neurohypophysial peptides


	Document type :	Parts of books : Contribution to collective works
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Human health sciences : Immunology & infectious disease Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/23400

Title :	Cellular and molecular aspects of thymic T-cell education to neurohypophysial peptides
Language :	English
Author, co-author :	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie - Embryologie >]
	Vandersmissen, Eric [Université de Liège - ULg > > Centre d'immunologie >]
	Martens, Henri [Université de Liège - ULg > > Endocrinologie clinique >]
	Goxe, Béatrice [Université de Liège - ULg > > Diabétologie,nutrition, maladies métaboliques >]
	Kecha, Ouafae [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire - GIGA-R : Coordination scientifique >]
	Legros, Jean-Jacques [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Lefebvre, Pierre [> > > >]
	Benhida, Abdellah [> > > >]
	Rentier-Delrue, Françoise [> > > >]
	Martial, Joseph [> > > >]
Publication date :	1995
Main document title :	Neurohypophysis - Recent Progress of Vasopressin and Oxytocin Research
Author, co-author :	Yoshida, Sho
Editor :	Saito, Toshikazu
	Kurokawa, Kiyoshi
Publisher :	Elsevier Science
Pages :	309-319
City :	New York
Country :	USA
Abstract :	[en] Our studies have shown that oxytocin (OT) is the dominant peptide of the neurohypophysial (NHP) family that is expressed by thymic epithelial/nurse cells (TEC/TNC). Both in specific RIA and ICC analyses, vasopressin (VP) immunoreactivity is considerably lower in TEC. OT is not secreted by TEC/TNC, but it is presented as the self antigen of the NHP family to developing pre-T cells. The process of T-cell education in recognizing the NHP family involves an active cooperation between this neuroendocrine gene/protein family and the immunoglobulin family. This cooperation is illustrated by the identification in plasma membranes of human TEC of a 55-kDa protein bearing a neurophysin (10 kDa), as well as a MHC class I heavy chain-related domain (45 kDa). Since both OT and VP genes are transcribed in the thymus, the site of this cooperation should be located at posttranscriptional level. From these data, it appears that thymic T-cell education to the NHP family involves specific pathways which are not strictly superimposible to those dlineated using peripheral dedicated APC. Although MHC class I pathways are needed, it appears that thymic T-cell education to NHP self is not restricted in an allelic fashion. This offers significant advantages for the selection of the human T-cell repertoire. Furthermore, the absence of a tight MHC allelic restriction in the process of T-cell education to neuroendocrine self opens novel perpectives for the prevention of autoimmune endocrine disorders such as insulin-dependent diabetes mellitus.
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Permalink :	http://hdl.handle.net/2268/23400

There is no file associated with this reference.

All documents in ORBi are protected by a user license.

Dspace v1.5