Pregnancy and the immune system: between tolerance and rejection

[en] Interactions between the conceptus and the mother are bi-directional: the feto-placental tissues need nutrition and a suitable environment in homeostatic condition whereas the mother influenced by the placental factors adapts her metabolism and immune system. Many different mechanisms acting locally or at distance ensure tolerance of the semi-allogeneic graft by the maternal natural and adaptive immune defences. In front of this tolerance, mechanisms exist ensuring rejection of the conceptus by the mother (spontaneous abortion) through rupture of one or more tolerance mechanisms, notably in stress situations endangering the mother. Thus outcome of a pregnancy is dependent on efficiently working tolerance mechanisms, and rupture of such mechanisms can lead to rejection. The balance of influence leading either to tolerance or rejection is under control of internal (maternal and fetal) and external (environmental) factors. Rejection, if triggered, mainly occurs through immune-induced inflammation, tissue degradation and coagulation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Thellin, Olivier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Language :

English

Title :

Pregnancy and the immune system: between tolerance and rejection

Publication date :

01 April 2003

Journal title :

Toxicology

ISSN :

0300-483X

eISSN :

1879-3185

Publisher :

Elsevier Sci Ireland Ltd, Clare, Ireland

Volume :

185

Issue :

Pages :

179-184

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 September 2009

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