Article (Scientific journals)
Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation.
Kuijpers, Marijke; Schulte, V.; Oury, Cécile et al.
2004In Journal of Physiology
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Keywords :
platelets; adhesion receptors; flow
Abstract :
[en] This work indicates that, under physiological conditions of flow, both adhesive receptors GPIb and alphaIIbbeta3 facilitate GPVI-mediated PS exposure by stabilizing platelet binding to collagen. Hence, these glycoproteins have an assistant procoagulant role in collagen-dependent thrombus formation, which is most prominent at reduced GPVI activity and is independent of the presence of thrombin.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Kuijpers, Marijke;  Universiteit Maastricht > Biochemistry > CARIM
Schulte, V.;  Universiteit Maastricht > Biochemistry > CARIM
Oury, Cécile  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine
Lindhout, T.;  Universiteit Maastricht > CARIM
Broers, J.;  Universiteit Maastricht > CARIM
Hoylaerts, Marc F;  Katholieke Universiteit Leuven - KUL > CMVB
Nieswandt, B.;  University of Wurzburg > Rudolf Virchow Center for experimental biomedicine
Heemskerk, Johan W M;  Universiteit Maastricht > Biochemistry > CARIM
Language :
English
Title :
Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation.
Publication date :
2004
Journal title :
Journal of Physiology
ISSN :
0022-3751
eISSN :
1469-7793
Publisher :
Blackwell Publishing, New York, United States - New York
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 September 2009

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