Reference : Ultrastructure of CD57+ cells isolated from human tonsils or blood.
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Ultrastructure of CD57+ cells isolated from human tonsils or blood.
Bouzahzah, F. [> > > >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
Bosseloir, A. [> > > >]
Mancini, I. [> > > >]
Simar, L. J. [> > > >]
European Journal of Morphology
Taylor & Francis
Yes (verified by ORBi)
United Kingdom
[en] Antibodies, Monoclonal/immunology ; Antigens, CD/immunology ; Antigens, CD57 ; Antigens, Differentiation, T-Lymphocyte/immunology ; Cell Separation ; Child ; Humans ; Immunosorbent Techniques ; Killer Cells, Natural/ultrastructure ; Leukocytes, Mononuclear/ultrastructure ; Magnetics ; Microspheres ; Palatine Tonsil/ultrastructure ; Rosette Formation ; T-Lymphocyte Subsets/ultrastructure
[en] The presence of CD4+, CD57+ T cells in the germinal centers has been reported by several authors. The CD57 antigen is also expressed by natural killer (NK) cells. We purified CD57+ cells from human tonsils and blood by microdissection, rosetting with sheep red blood cells and magnetic cell sorting (MACS) and examined the ultrastructural morphology of these cells. Clear differences were found in cell aspect: blood NK contained large granules which were not found in the tonsillar CD57+ cells. These latter appeared medium-sized and not fully activated. After immunolabeling, the tonsillar CD57+ cells were mainly found in the light zone of the germinal centers.

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