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Article (Scientific journals)
Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Tsunoda, R.; Nakayama, M.; Heinen, Ernst et al.
1992In Virchows Archiv. B: Cell Pathology, 62 (2), p. 69-78
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Keywords :
Antigens, Differentiation/metabolism; Cell Adhesion/physiology; Dendritic Cells/immunology/physiology/ultrastructure; Humans; Immunoenzyme Techniques; Lymphocytes/physiology/ultrastructure; Microscopy; Microscopy, Phase-Contrast; Palatine Tonsil/cytology
Abstract :
[en] Isolated follicular dendritic cells (FDCs) showed true and pseudoemperipolesis of fresh tonsillar lymphocytes, even after long-term (50-day) cultivation. Emperipolesis by FDCs was not restricted by allotype specificity, nor was it inhibited by the addition of antibodies against MHC-I & II antigens. Follicular dendritic cells predominantly engulfed B-cells; monocytes and macrophages were not found between FDC cytoplasmic extensions. When highly purified T-cell populations were added to FDC cultures emperipolesis of T-cells occurred, particularly those of the CD4-positive phenotype. Mitoses appeared within 6 h in the emperipolesed lymphocytes and, after an additional 18 h, some lymphocytes exhibited apoptosis.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Tsunoda, R.
Nakayama, M.
Heinen, Ernst ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Miyake, K.
Suzuki, K.
Sugai, N.
Kojima, M.
Language :
English
Title :
Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Publication date :
1992
Journal title :
Virchows Archiv. B: Cell Pathology
ISSN :
0340-6075
Publisher :
Springer Verlag, Berlin, Germany
Volume :
62
Issue :
2
Pages :
69-78
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 September 2009

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