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Keywords :
5'-Nucleotidase; Animals; Histocytochemistry; Lymph Nodes/enzymology/immunology/ultrastructure; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nucleotidases/metabolism; Receptors, Fc/metabolism
Abstract :
[en] Follicular dendritic cells isolated from mouse lymph nodes were incubated in the presence of AMP to test 5-nucleotidase (5-Nase) activity. Ultrastructural observations showed the presence of 5-Nase on external membranes but also some activity inside the nucleus. 5-Nase was found associated to Fc receptors labelled with homologous immunoglobulins fixed on colloidal gold particles. Lymphocytes and macrophages, found in association with the follicular dendritic cells, were either 5-Nase positive or negative. The hypothetical roles played by 5-Nase in germinal centers are discussed.
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