|Reference : Follicular dendritic cells in lymph nodes after x-irradiation.|
|Scientific journals : Article|
|Life sciences : Anatomy (cytology, histology, embryology...) & physiology|
|Follicular dendritic cells in lymph nodes after x-irradiation.|
|Kinet-Denoel, C. [> > > >]|
|Heinen, Ernst [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]|
|Radoux, Dominique [Centre Hospitalier Universitaire de Liège - CHU > > DIALYSE (SN +6) >]|
|Simar, L. J. [> > > >]|
|International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine|
|Taylor & Francis|
|Yes (verified by ORBi)|
|[en] Animals ; Female ; Intercellular Junctions ; Lymph Nodes/radiation effects/ultrastructure ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron ; Whole-Body Irradiation|
|[en] Follicular dendritic cells (FDC), non lymphoid cells present in lymph follicles, are characterized by numerous cytoplasmic processes retaining antigen-antibody complexes. Their origin, nature and function are unknown. Mice inguinal lymph nodes after 4.5 or 7.5 Gy X-irradiation were depleted of lymphoid cells. Ultrastructural observations during the first few days post-irradiation show that FDC are unaltered and possess dendritic processes enveloping dense material. Furthermore, they show intense metabolic activity. A lamina densa, never observed so well-developed in other lymph node cells, was detected around the nuclear envelope. The localization of junctions between FDC was analysed. FDC preserve their typical cytoplasmic processes even if lymphoid cells are rare. The latter thus seem not to be responsible for the maintenance of FDC integrity or their development. The possible role of this for antibody production is discussed. Irradiated lymph nodes of lymphoid cells are highly convenient for studying FDC. Isolation of FDC from irradiated lymph organs would seem to be possible.|
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