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Relations entre immunogénicité et différenciation des métastases d'un mélanome expérimental chez la souris.
Heinen, Ernst; Beckers, Josiane; Desaive, Claude et al.
1982In Comptes Rendus des Séances de la Société de Biologie et de ses Filiales, 176 (2), p. 223-6
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Keywords :
Animals; Cell Differentiation; Kinetics; Melanoma/immunology/physiopathology; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms, Experimental/immunology/physiopathology
Abstract :
[en] The graft into the footpad of Jackson mice of B16 melanoma cells which are only slightly pigmented, induces the simultaneous appearance of achromatic and well-pigmented metastatics. We have analysed histologically both types of metastases from the 8th to the 20th day after the resection of the primary tumor. The percentages of mitoses are higher in the achromatic metastases than in the pigmented ones. Both are infiltrated by lymphocytes and by a small number of macrophages and polymorphonuclears. A statistical analysis demonstrates however that the percentage of lymphocytes is not related to the importance of the metastase pigmentation. The discussion is devoted to the relations between the infiltration by lymphocytes, the immunogenicity and the differentiation of the tumor.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Heinen, Ernst ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Beckers, Josiane ;  Centre Hospitalier Universitaire de Liège - CHU > Rééducation de la parole
Desaive, Claude ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Lennes, G.
Simar, L.
Language :
French
Title :
Relations entre immunogénicité et différenciation des métastases d'un mélanome expérimental chez la souris.
Alternative titles :
[en] Relation between immunogenicity and differentiation of metastasis in an experimental murine melanoma
Publication date :
1982
Journal title :
Comptes Rendus des Séances de la Société de Biologie et de ses Filiales
ISSN :
0037-9026
eISSN :
2437-3532
Publisher :
Masson Publishing, France
Volume :
176
Issue :
2
Pages :
223-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 September 2009

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