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Article (Scientific journals)
Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells.
Delsarte, Anne; Faway, Michel; Frère, Jean-Marie et al.
1981In Antimicrobial Agents and Chemotherapy, 19 (3), p. 477-86
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Keywords :
Anti-Bacterial Agents/metabolism/pharmacology; Bacteria/drug effects; Biotransformation; Escherichia coli/drug effects/growth & development/ultrastructure; Nitrofurans/metabolism/pharmacology
Abstract :
[en] This paper presents a study of the interactions between Escherichia coli cells and nifurzide, a nitrofuran derivative which is used as an intestinal antiinfectious agent. At low concentrations of nifurzide, the growth rate of the cultures decreased, and elongated, nonseptate cells appeared. At high concentrations, complete growth inhibition occurred, accompanied by a rather strong bactericidal effect, but the appearance of the cells was normal; in particular, no bacteriolytic effect was observed. A very large number of antibiotic molecules were bound per bacterial cell. After cell disruption, similar amounts of nifurzide were found in the cytoplasm, cytoplasmic membranes, and cell wall, respectively. Most of the bound nifurzide was rapidly degraded or became protein bound. The structure of the outer membrane lipopolysaccharide appeared to have little influence on the activity of nifurzide.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Delsarte, Anne
Faway, Michel
Frère, Jean-Marie ;  Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Coyette, Jacques
Calberg-Bacq, Claire-Michelle
Heinen, Ernst ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine
Language :
English
Title :
Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells.
Publication date :
1981
Journal title :
Antimicrobial Agents and Chemotherapy
ISSN :
0066-4804
eISSN :
1098-6596
Publisher :
American Society for Microbiology (ASM), Washington, United States - District of Columbia
Volume :
19
Issue :
3
Pages :
477-86
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 September 2009

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