Reference : Interleukin-1 Beta Induces Nuclear Factor Kappa B in Epithelial Cells Independently of t...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/2312

Title :	Interleukin-1 Beta Induces Nuclear Factor Kappa B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates
Language :	English
Author, co-author :	Bonizzi, Giuseppina [> > > >]
	Dejardin, Emmanuel [Université de Liège - ULg > > Virologie - Immunologie >]
	Piret, Bernard [> > > >]
	Piette, Jacques [Université de Liège - ULg > Département des sciences de la vie > Virologie - Immunologie >]
	Merville, Marie-Paule [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
	Bours, Vincent [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine]
Publication date :	15-Dec-1996
Journal title :	European Journal of Biochemistry
Volume :	242
Issue/season :	3
Pages :	544-9
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0014-2956
Abstract :	[en] A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) in various cell types. Several studies have indicated that NF-kappa B activation depends strictly on the production of reactive oxygen intermediates. In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines (OVCAR-3, SKOV-3, MCF7 A/Z). In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105. We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2. Our study demonstrated that several signaling pathways lead to the activation of NF-kappa B, following IL-1 beta treatment in different cell types.
Permalink :	http://hdl.handle.net/2268/2312

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