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| Reference : Hsv-1 Thymidine Kinase Gene Therapy for Colorectal Adenocarcinoma-Derived Peritoneal Car... |
| Scientific journals : Article | |||
| Human health sciences : Multidisciplinary, general & others | |||
| http://hdl.handle.net/2268/2311 | |||
| Hsv-1 Thymidine Kinase Gene Therapy for Colorectal Adenocarcinoma-Derived Peritoneal Carcinomatosis | |
| English | |
Lechanteur, Chantal  [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >] | |
| Princen, Frédéric [> > > >] | |
| Lo Bue, S. [> > > >] | |
| Detroz, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >] | |
| Fillet, Georges [Université de Liège - ULg > Département des sciences cliniques > Hématologie - Oncologie médicale] | |
| Gielen, Jean-Louis [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie maxillo-faciale et plastique >] | |
| Bours, Vincent [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine] | |
| Merville, Marie-Paule [Université de Liège - ULg > Département de pharmacie > Chimie médicale >] | |
| Nov-1997 | |
| Gene Therapy | |
| 4 | |
| 11 | |
| 1189-94 | |
| International | |
| 0969-7128 | |
| [en] Peritoneal carcinomatosis is a common clinical situation which, in most cases, cannot be eradicated by surgery or chemotherapy. The feasibility of an HSV-TK-based suicide gene therapy for peritoneal carcinomatosis induced by DHD/K12 colon carcinoma cells was investigated. DHD/K12 cells stably expressing the tk gene were killed in vitro in the presence of low concentrations of ganciclovir, they exhibited a 'bystander effect' when mixed with TK-negative cells. BD-IX rats injected intraperitoneally, either directly or after surgical peritoneal irritations, with DHD/K12 cells developed peritoneal carcinomatosis within 2 weeks. Ganciclovir treatment of animals injected with DHD/K12-TK cells allowed a significant reduction of the tumor volume as well as a prolonged survival. Of these animals 35-40% showed a long-term disease-free survival after ganciclovir therapy. Residual or relapsing tumors could be explained by a low expression of the transgene as demonstrated by RT-PCR. | |
| http://hdl.handle.net/2268/2311 |
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