[en] Serum selenium (Se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (ANLL). Pre-treatment serum Se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, P less than 0.01). Pretreatment serum Se correlated inversely with the absolute peripheral blast cell count (R = -0.62, P less than 0.001) and other measurements of the tumor burden. Seven days after the initiation of chemotherapy, serum Se increased significantly in proportion to the initial tumor burden (P less than 0.01). Thereafter, serum Se levels remained essentially normal in patients entering a complete remission while decreasing gradually in failures. In conclusion, these data do not lend support to the hypothesis that a low selenium status enhances the risk of developing ANLL, but indicate that serum Se levels in patients with acute leukemia are mostly dependent on tumor activity.
Disciplines :
Hematology
Author, co-author :
Beguin, Yves ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Delbrouck, J. M.
Robaye, G.
Roelandts, I.
Bury, J.
Fillet, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Weber, Georges ; Université de Liège - ULiège > Département de physique > Physique nucléaire, atomique et spectroscopie
Language :
English
Title :
Relationship of Serum Selenium Levels to Tumor Activity in Acute Non-Lymphocytic Leukemia
Ip, C. (1986) Selenium and experimental cancer. Ann. Clin. Res., 18, 22-29.
Ip, C. (1985) Selenium inhibition of chemical carcinogenesis. Fed. Proc., 44, 2573-2578.
Clark, L.C. (1985) The epidemiology of selenium and cancer. Fed. Proc., 44, 2584-2589.
Kok, F.J., De Bmijn, A.M., Hofman, A., Vermeeren, R. and Valkenburg, H.A. (1987) Is scrum selenium a risk factor for cancer in men only? Am. J. Epidemiol., 125, 12-16.
Salonen, J.T., Alfthan, G., Huttunen, J.K. and Puska, P. (1984) Association between serum selenium and the risk of cancer. Am. J. Epidemiol., 120, 342-349.
Salonen, J.T., Salonen, R., Lappetelainen, R., Maenpaa, P.H., Alfthan, G. and Puska, P. (1985) Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. Br. Med. J., 290, 417-420.
Willett, W., Polk, B., Morris, S., Stampfer, M.J., Pressel, S., Rosner, B., Taylor, J.O., Schneider, K. and Hames, C.G. (1983) Prediagnostic serum selenium and risk of cancer. Lancet, 2, 130-134.
Broghamer, W.L. Jr, McConnell, K.P. and Blotcky, A.L. (1976) Relationship between serum selenium levels and patients with carcinoma. Cancer, 37, 1384-1388.
Shamberger, R.J., Rukovena, E., Longfield, A.K., Tytko, S.A., Deodhar, S. and Willis, C.E. (1973) Antioxidants and cancer. 1. Selenium in the blood of normal and cancer patients. J. Natl. Cancer Inst., 50, 863-870.
Sundstrom, H., Ylikorkala, O. and Kauppila, A. (1986) Serum selenium and thromboxane in patients wtih gynaecological cancer. Carcinogenesis, 7, 1051-1052.
Sundstrom, H., Korpela, H., Viinikka, L. and Kauppila, A. (1984) Serum selenium and glutathione peroxidase, and plasma lipid peroxides in uterine, ovarian or vulvar cancer, and their responses to antioxidants in patients with ovarian cancer. Cancer Lett., 24, 1-10.
Sundstrom, H., Yrjanheikki, E. and Kauppila, A. (1984) Low serum selenium concentration in patients with cervical or endometrial cancer. Im. J. Gynaecol. Obstet., 22, 35-40.
Calautti, P., Moschini, G., Stievano, B.M., Tomio, L., Calzavara, F. and Perona, G. (1980) Serum selenium levels in malignant lymphoproliferative diseases. Scand. J. Haematol., 24, 63-66.
Corrocher, R., Casaril, M., BeDisola, G., Gabrielli, G., Hulpe, M., Garofoli, E. and Nicoli, N. (1986) Reduction of liver glutathione peroxidase activity and deficiency of serum selenium in patients with hepatocellular carcinoma. Tltmori, 72, 617-619.
Dworkin, B.M., Rosenthal, W.S., Mittelman, A., Weiss, L., Apptebee-Brady, L. and Arlin, Z. (1988) Selenium status and the polyp-cancer sequence: a colono- scopically controlled study. Am. J. Gastroenterol., 83, 748-751.
Pothier, L., Lane, W.W., Bhargava, A., Michtelson, C. and Douglass, H.O. (1987) Plasma selenium levels in patients with advanced upper gastrointestinal cancer. Cancer, 60, 2251-2260.
Johansson, T.B., Akselsson, R. and Johansson, S.A.E. (1970) Elemental trace element analysis at the 10“12 level. Nucl. Instrum. Methods, 84, 141-143.
McConnell, K.P., Broghamer, W.L. Jr, Blotcky, A.J. and Hurt, O.J. (1975) Selenium levels in human blood and tissues in health and in disease. J. Nutrition, 105, 1026-1031.
Beguin, Y., Brasseur, F., Weber, G., Bury, J., Delbrouck, J.-M., Roelandts, I., Robaye, G. and Fillet, G. (1987) Observations of serum trace elements in chronic lymphocytic leukemia. Cancer, 60, 1842-1846.
Lee, G.R. (1983) The anemia of chronic disease. Sem. Hematol., 20, 61-80.
Broghamer, W.L. Jr, McConnell, K.P., Grimaldi, M. and Blotcky, A.J. (1978) Serum selenium and reticuloendothelial tumors. Cancer, 41, 1462-1466.
Di Ilio, C., Del Boccio, G., Casaccia, R., Aceto, A., Di Giacomo, F. and Federici, G. (1987) Selenium level and glutathione-dependent enzyme activities in normal and neoplastic human lung tissues. Carcinogenesis, 8, 281-284.
Cavalieri, R.R., Scott, K.C. and Sairene, E. (1966) Selenite as a tumor-localizing agent in man. J. Nucl. Med., 7, 197-208.
Ringstad, J., Jacobsen, B.K., Tretli, S. and Thomassen, Y. (1988) Serum selenium concentration associated with risk of cancer. J. Clin. Pathol., 41, 454-457.
Menkes, M.S., Comstock, G.W., Vuilleumier, J.P., Helsing, KJ., Rider, A.A. and Brookmeyer, R. (1986) Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N. Engl. J. Med., 315, 1250-1254.
Nomura, A., Heilbrun, L.K., Morris, J.S. and Stemmermann, G.N. (1987) Serum selenium and the risk of cancer, by specific sites: case-control analysis of prospective data. J. Natl. Cancer Inst., 79, 103-108.
Clark, L.C. and Combs, G.F Jr (1986) Selenium compounds and the prevention of cancer: research needs and public health implications. J. Nutrition, 116, 170-173.
