Article (Scientific journals)
In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria
Bero, Joanne; Ganfon, Habib; Jonville, Marie et al.
2009In Journal of Ethnopharmacology, 122, p. 439-444
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Keywords :
antiplasmodial activity; Benin Traditional medicine; Acanthospermum hispidum; Keetia leucantha; Carpolobia lutea; Strychnos spinosa
Abstract :
[en] Aim of the study: The aim of the studywas to evaluate the in vitro antiplasmodial activity of crude extracts of 12 plant species traditionally used in Benin for the treatment of malaria in order to validate their use. Materials and methods: For each species, dichloromethane, methanol and total aqueous extracts were tested. The antiplasmodial activity of extracts was evaluated using the measurement of the plasmodial lactate dehydrogenase activity on chloroquine-sensitive (3D7) and resistant (W2) strains of Plasmodium falciparum. The selectivity of the different extractswas evaluated using the MTT test on J774 macrophagelike murine cells and WI38 human normal fibroblasts. Results: The best growth inhibition of both strains of Plasmodium falciparum was observed with the dichloromethane extracts of Acanthospermum hispidum DC. (Asteraceae) (IC50 =7.5 g/ml on 3D7 and 4.8 g/ml on W2), Keetia leucantha (K. Krause) Bridson (syn. Plectronia leucantha Krause) (Rubiaceae) leaves and twigs (IC50 = 13.8 and 11.3 g/ml on 3D7 and IC50 = 26.5 and 15.8 g/ml on W2, respectively), Carpolobia lutea G.Don. (Polygalaceae) (IC50 = 19.4 g/ml on 3D7 and 8.1 g/ml on W2) and Strychnos spinosa Lam. (Loganiaceae) leaves (IC50 = 15.6 g/ml on 3D7 and 8.9 g/ml on W2). All these extracts had a low cytotoxicity. Conclusion: Our study gives some justifications for the traditional uses of some investigated plants.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Bero, Joanne;  Université Catholique de Louvain - UCL
Ganfon, Habib;  Université Catholique de Louvain-UCL ; Université d'Abomey Calavi (Bénin)
Jonville, Marie ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Gbaguidi, Fernand;  Centre Béninois de la Recherche Scientifique et Technique (Bénin)
De Mol, Patrick ;  Centre Hospitalier Universitaire de Liège - CHU > Microbiologie médicale
Moudachirou, Mansourou;  Centre Béninois de la Recherche Scientifique et Technique ; Université d'Abomey Calavi (Bénin)
Quetin-Leclercq, Joëlle;  Université Catholique de Louvain - UCL
Language :
English
Title :
In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria
Publication date :
2009
Journal title :
Journal of Ethnopharmacology
ISSN :
0378-8741
eISSN :
1872-7573
Publisher :
Elsevier Sequoia, Limerick, Ireland
Volume :
122
Pages :
439-444
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 April 2009

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