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Thymus Gland, Neuroendocrinology
Geenen, Vincent; Robert, Françoise; Ericsson, Anders et al.
1992In Smith, Barry; Adelman, George (Eds.) The Neuroscience Year, Supplement 2 to the Encyclopedia of Neuroscience
 

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Abstract :
[en] T-cell differentiation occurs primarily within the thymus and is regulated through intimate intercellular contacts, interactions between major histocompatibility proteins and the T-cell receptor complex, as well as exchanges of peptide signals between immature lymphocytes and thymic environmental cellular populations. There is now ample evidence that neuropeptide-lymphocyte interactions occur at multiple levels in the thymus, and that the sources of neuropeptides are encountered in different sites such as thymic innervating fibers, stromal cells, and developing thymocytes themselves. An important question to consider is the fact that neuropeptides are intrinsic components of the 'self' molecular structure, and therefore may contribuye to the induction of T-cell self tolerance. After immature thymocytes have escaped the deletion process of clones highly reactive for 'self' peptides, thymic neuropeptides could also represent accessory signals for activation (or inhibition) steps in the developmental programme of the T-cell system.
Disciplines :
Endocrinology, metabolism & nutrition
Immunology & infectious disease
Author, co-author :
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie - Embryologie
Robert, Françoise
Ericsson, Anders;  Karolinska Institutet > Laboratory of Molecular Biology
Persson, Hakan;  Karolinska Institutet > Laboratory of Molecular Neurobiology
Language :
English
Title :
Thymus Gland, Neuroendocrinology
Publication date :
1992
Main work title :
The Neuroscience Year, Supplement 2 to the Encyclopedia of Neuroscience
Editor :
Smith, Barry
Adelman, George
Publisher :
Birkhäuser Verlag, Boston, United States
ISBN/EAN :
0-8176-3507-6
Pages :
149-150
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 21 September 2009

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