ORBi: Adler Michael - Outcome of Patients with Hepatocellular Carcinoma Listed for Liver Transplantation Within the Eurotransplant Allocation System

Reference : Outcome of Patients with Hepatocellular Carcinoma Listed for Liver Transplantation Withi...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Surgery Human health sciences : Oncology Human health sciences : Gastroenterology & hepatology
	To cite this reference:	http://hdl.handle.net/2268/2297

Title :	Outcome of Patients with Hepatocellular Carcinoma Listed for Liver Transplantation Within the Eurotransplant Allocation System
Language :	English
Author, co-author :	Adler, Michael [> >]
	De Pauw, Filip [> >]
	Vereerstraeten, Pierre [> >]
	Fancello, Agnese [> >]
	Lerut, Jan [> >]
	Starkel, Peter [> >]
	Van Vlierberghe, Hans [> >]
	Troisi, Roberto [> >]
	Donckier, Vincent [> >]
	Detry, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	Delwaide, Jean [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
	Michielsen, Pieter [> >]
	Chapelle, Thierry [> >]
	Pirenne, Jacques [> >]
	Nevens, Frederik [> >]
Publication date :	Mar-2008
Journal title :	Liver Transplantation
Publisher :	Wiley
Volume :	14
Pages :	526-533
Audience :	International
ISSN :	1527-6465
e-ISSN :	1527-6473
City :	New York
Country :	NY
Keywords :	[en] hepatocarcinoma ; results ; liver transplantation
Abstract :	[en] Although hepatocellular carcinoma (HCC) has become a recognized indication for liver transplantation, the rules governing priority and access to the waiting list are not well defined. Patient- and tumor-related variables were evaluated in 226 patients listed primarily for HCC in Belgium, a region where the allocation system is patient-driven, priority being given to sicker patients, based on the Child-Turcotte-Pugh (CTP) score. Intention-to-treat and posttransplantation survival rates at 4 years were 56.5 and 66%, respectively, and overall HCC recurrence rate was 10%. The most significant predictors of failure to receive a transplant in due time were baseline CTP score equal to or above 9 (relative risk [RR] 4.1; confidence interval [CI]: 1.7-9.9) and alpha fetoprotein above 100 ng/mL (RR 3.0; CI: 1.2-7.1). Independent predictors of posttransplantation mortality were age equal to or above 50 years (RR 2.5; CI: 1.0-3.7) and United Network for Organ Sharing pathological tumor nodule metastasis above the Milan criteria (RR 2.1; CI: 1.0-5.9). Predictors of recurrence (10%) were _ fetoprotein above 100 ng/mL (RR 3.2; CI:1.1-10) and vascular involvement of the tumor on the explant (RR 3.6; CI: 1.1-11.3). Assessing the value of the pretransplantation staging by imaging compared to explant pathology revealed 34% accuracy, absence of carcinoma in 8.3%, overstaging in 36.2%, and understaging in 10.4%. Allocation rules for HCC should consider not only tumor characteristics but also the degree of liver impairment. Patients older than 50 years with a stage above the Milan criteria at transplantation have a poorer prognosis after transplantation.
Target :	Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/2268/2297

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