Reference : Fusogenic Segments Of Bovine Leukemia-Virus And Simian Immunodeficiency Virus Are Int...
Scientific journals : Article
Life sciences : Animal production & animal husbandry
Life sciences : Veterinary medicine & animal health
Fusogenic Segments Of Bovine Leukemia-Virus And Simian Immunodeficiency Virus Are Interchangeable And Mediate Fusion By Means Of Oblique Insertion In The Lipid Bilayer Of Their Target-Cells
Voneche, V. [> > > >]
Portetelle, Daniel mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Kettmann, Richard [Université de Liège > > Gembloux Agro-Bio Tech >]
Willems, Luc mailto [Université de Liège > > GIGA-Research >]
Limbach, K. [> > > >]
Paoletti, E. [> > > >]
Ruysschaert, Jm. [> > > >]
Burny, A. [> > > >]
Brasseur, Robert mailto [Université de Liège > > Gembloux Agro-Bio Tech >]
Proceedings of the National Academy of Sciences of the United States of America
Yes (verified by ORBi)
[en] Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates that (i) both BLV envelope glycoproteins gp51 and gp30 are necessary for cell fusion; (ii) insertion of the N-terminal segment of gp30 (fusion peptide) into the lipid bilayer in an oblique orientation, as predicted by computer conformational analysis, results in fusogenic capacities higher than insertion in a perpendicular or parallel orientation; and (iii) replacement of the BLV fusion peptide with its simian immunodeficiency virus counterpart does not modify the fusogenic capacity of the BLV glycoprotein.
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