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Nuclear Localization of a New C-Cbl Related Protein, Carp 90, During in Vivo Thymic Apoptosis in Mice
Denis, Ghislaine; Mandard, S.; Verlaet, Myriam et al.
1999In Cell Death and Differentiation, 6 (7), p. 689-97
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Keywords :
thymus; apoptosis; c-cbl
Abstract :
[en] This study investigates the involvement of the c-cbl protooncogene in thymocyte apoptosis occurring in vivo after hydrocortisone treatment. In the thymus of untreated mice, a few medullary and cortical thymocytes expressed p120cbl, mainly in the cytoplasm. In the cortex, their number and distribution resemble that of apoptotic cells evidenced by TUNEL staining. The expression of Cbl is rapidly increased when apoptosis is triggered by hydrocortisone. This Cbl-specific immunostaining was detected in the nucleus and is due to a Cbl-related 90 kDa protein (CARP 90). These results show that a c-cbl product could localize in the nucleus and suggest that it could be involved as a regulator of thymic apoptosis.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Denis, Ghislaine;  Université de Liège - ULiège - Département des sciences biomédicales et précliniques - Histologie Cytologie - GIGA-R
Mandard, S.
Verlaet, Myriam ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Stehelin, D.
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Regnier, D.
Language :
English
Title :
Nuclear Localization of a New C-Cbl Related Protein, Carp 90, During in Vivo Thymic Apoptosis in Mice
Publication date :
July 1999
Journal title :
Cell Death and Differentiation
ISSN :
1350-9047
eISSN :
1476-5403
Publisher :
Nature Publishing Group, United Kingdom
Volume :
6
Issue :
7
Pages :
689-97
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 May 2010

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