Reference : The Thymic Repertoire of Neuroendocrine Self-Antigens: Physiological Implications in T-C...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Endocrinology, metabolism & nutrition Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/22864

Title :	The Thymic Repertoire of Neuroendocrine Self-Antigens: Physiological Implications in T-Cell Life and Death
Language :	English
Author, co-author :	Martens, Henri [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Embryologie >]
	Goxe, B. [> > > >]
	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie >]
Publication date :	Jul-1996
Journal title :	Immunology Today
Volume :	17
Issue/season :	7
Pages :	312-7
Audience :	International
ISSN :	0167-5699
Abstract :	[en] During phylogeny aud ontogeny, the thymus appears as a crucial meeting point between the neuroendocrine aud immune systems. Through cryptocrine intercellular communication, thymic neuroendocrine-related precursors can influence the early steps of the immune response, while T-cell precursors are educated to recognize the principal neuroendocrine families. Here, we summarize the observations that support the dual role of the thymic repertoire of neuroendocrine-related polypeptidte precursors in T-cell differentiation.
Permalink :	http://hdl.handle.net/2268/22864

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