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| Reference : Thymus dysfunction in the development of type 1 diabetes and endocrine autoimmune diseases |
| Scientific journals : Article | |||
| Human health sciences : Endocrinology, metabolism & nutrition Human health sciences : Immunology & infectious disease | |||
| http://hdl.handle.net/2268/22846 | |||
| Thymus dysfunction in the development of type 1 diabetes and endocrine autoimmune diseases | |
| English | |
Geenen, Vincent  [Université de Liège - ULg > > Centre d'immunologie - Embryologie >] | |
| Dardenne Olivier [Université de Liège - ULG > Centre d'Immunologie - CIL > > >] | |
| 2009 | |
| European Endocrinology | |
| 5 | |
| 24-26 | |
| International | |
| [en] Thymus ; Self-tolerance ; Autoimmunity | |
| [en] The discovery that thymic epithelium from many species expresses a large repertoire of genes encoding neuroendocrine and other tissue-restricted antigens has radically changed our knowledge of the pathogenic mechanisms underlying the development of organ-specific autoimmune diseases such as type 1 diabetes and autoimmune endocrine diseases. Rather than a breakdown of immunological selftolerance
in periphery, there is mounting evidence that the diabetogenic autoimmune response may first arise from a thymus dysfunction in the central programming of β-cell self-tolerance. Insulin-like growth factor 2 (IGF-2) is the dominant member of the insulin gene/protein family expressed in thymic epithelial cells (TECs) from different species, and Igf2-/- mice fail to programme complete tolerance to insulin. Based on the homology between insulin, the primary and immunogenic auto-antigen of type 1 diabetes, and IGF-2, the tolerogenic self-antigen of the insulin family, the design of a regulatory/negative self-vaccination for prevention against type 1 diabetes has been proposed and is under development. | |
| Centre d'Immunologie - CIL | |
| Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Eurothymaide FP6 Integrated Project ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/22846 |
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