Controlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroimaging Research

[en] Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates of controlled processes. Accordingly, controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer's disease (QAD). The patients' brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study. Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure. The results demonstrated the central role of a medial frontal-posterior cingulate network for controlled processing of episodic memory in the early stages of AD.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron

Kerrouche N

Lekeu, Françoise ; Université de Liège - ULiège > Neurologie Sart Tilman - Gériatrie

Adam, Stéphane ; Université de Liège - ULiège > Département de personne et société > Psychologie de la sénescence

Guillaume B

Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Aerts, Joël ; Université de Liège - ULiège > Centre de recherches du cyclotron

d'Idewalle G

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Controlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroimaging Research

Publication date :

June 2010

Journal title :

Journal of Alzheimer's Disease

ISSN :

1387-2877

eISSN :

1875-8908

Publisher :

IOS Press

Volume :

Issue :

Pages :

547-560

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20164554

Funders :

FNRS; IUAP; European project DIMI

Available on ORBi :

since 05 May 2010

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