Reference : Controlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroima...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/22647
Controlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroimaging Research
English
Bastin, Christine mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Kerrouche N [> >]
Lekeu, Françoise mailto [Université de Liège - ULg > > Neurologie Sart Tilman - Gériatrie >]
Adam, Stéphane mailto [Université de Liège - ULg > Département de personne et société > Psychologie de la sénescence >]
Guillaume B [> >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
d'Idewalle G [> >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Jun-2010
Journal of Alzheimer's Disease [=JAD]
IOS Press
20
2
547-560
Yes (verified by ORBi)
International
1387-2877
[en] Alzheimer ; neuroimaging ; controlled processes
[en] Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates of controlled processes. Accordingly, controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer's disease (QAD). The patients' brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study. Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure. The results demonstrated the central role of a medial frontal-posterior cingulate network for controlled processing of episodic memory in the early stages of AD.
Centre de Recherches du Cyclotron - CRC
FNRS; IUAP; European project DIMI
http://hdl.handle.net/2268/22647
10.3233/JAD-2010-1393
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20164554

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