Reference : Mycosis fungoides progression and chronic solvent exposure
Scientific journals : Article
Human health sciences : Dermatology
Mycosis fungoides progression and chronic solvent exposure
Nikkels, Arjen mailto [Université de Liège - ULg > > Dermatologie >]
Quatresooz, Pascale mailto [Université de Liège - ULg > > Dermatopathologie >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Balsat, A. [>>>>]
Pierard, Gérald mailto [Université de Liège - ULg > > Dermatopathologie >]
Dermatology : International Journal for Clinical & Investigative Dermatology
Yes (verified by ORBi)
[en] solvent ; mycosis fungoides ; occupational exposure ; T-cell receptor rearrangement ; interferon-alpha
[en] The effect of repeated exposure to specific chemicals on the initiation or progression of mycosis fungoides (MF) remains unsettled. A patient with low-grade patch stage MF progressively developed MF plaques restricted to his arms, and a tumour on his right thigh. These areas were subject to repeated exposure to solvents. His thigh was indeed in close contact with his trousers pocket where he used to store a wiping rag drenched into white spirit and cellulosic thinner. Immunophenotyping these lesions revealed a dense LCA+, CD2+, CD3+, CD4+, CD5+, CD7+, CD45+, CD45RO+ T-cell infiltrate admixed with many factor XIIIa+ dendrocytes. T-cell receptor rearrangement analysis identified a monoclonal T-cell infiltrate. An internal work-up remained negative. Stopping further solvent exposure failed to improve his condition. Oral corticotherapy combined with low-dose interferon-alpha2a halted disease progression. This observation suggests that long-term solvent exposure may trigger MF and hasten its progression from the patch stage to the plaque and tumour stages. Copyright (C) 2004 S. Karger AG, Basel.

File(s) associated to this reference

Fulltext file(s):

Open access
Dermatology 2004.pdfNo commentaryPublisher postprint2.57 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.