Phonological loop and central executive functioning in Alzheimer's disease

Alzheimers disease; Working memory; Phonological loop; Central executive; Heterogeneity; Ka-ALZHEIMER'S DISEASE; ka-central executive; Ka-HETEROGENEITY; Ka-PHONOLOGICAL LOOP; Ka-WORKING MEMORY

Abstract :

[en] The phonological loop and central executive functioning were examined in patients with Alzheimer's disease (AD) and in normal elderly subjects. AD patients showed abnormal functioning of the phonological loop and decreased performance on tasks assessing the central executive. However, when AD patients were separated into two groups on the basis of their span level, both groups showed deficits of the central executive but only patients with the lower span level presented a dysfunction of the phonological loop as well as impaired performance in tasks of phonological discrimination, articulation rate and speed of processing. These results are interpreted in terms of progression of the disease, with high-span level patients being less severely demented and displaying deficits only in higher-level cognitive functions (such as manipulation of information stored in working memory) whereas patients with a low span level have impairments encompassing a series of more basic processes.

Disciplines :

Neurosciences & behavior

Author, co-author :

Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie

Van der Linden, Martial ; Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive

Bechet, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > Neurochirurgie

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Language :

English

Title :

Phonological loop and central executive functioning in Alzheimer's disease

Publication date :

July 1999

Journal title :

Neuropsychologia

ISSN :

0028-3932

eISSN :

1873-3514

Publisher :

Elsevier, Oxford, United Kingdom

Volume :

Issue :

Pages :

905-918

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.elsevier.com/wps/find/journaldescription.cws_home/247/description#description

Available on ORBi :

since 17 September 2009

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