Reference : The emerging role of lysine acetylation of non-nuclear proteins
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/22412
The emerging role of lysine acetylation of non-nuclear proteins
English
[fr] Le rôle émergeant de l'acétylation des protéines non-nucléaires
Close, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Creppe, Catherine [ > > ]
Gillard, Magali [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
ladang, Aurélie [ > > ]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Apr-2010
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
67
8
1255-1264
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] acétylation ; HDAC ; HAT
[en] Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review
describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.
Giga-Signal Transduction, GIGA-Neurosciences
FNRS, TELEVIE, ARC ULG, FBC, Prix Suez Fonds Léon Frédéricq
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/22412

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