The emerging role of lysine acetylation of non-nuclear proteins

[en] Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.

Research center :

Giga-Neurosciences - ULiège
Giga-Signal Transduction - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Close, Pierre ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Creppe, Catherine

Gillard, Magali ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

LADANG, Aurélie ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique

Chapelle, Jean-Paul ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Nguyen, Laurent ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Chariot, Alain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Language :

English

Title :

The emerging role of lysine acetylation of non-nuclear proteins

Alternative titles :

[fr] Le rôle émergeant de l'acétylation des protéines non-nucléaires

Publication date :

April 2010

Journal title :

Cellular and Molecular Life Sciences

ISSN :

1420-682X

eISSN :

1420-9071

Publisher :

Birkhäuser, Basel, Switzerland

Volume :

Issue :

Pages :

1255-1264

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Fonds Léon Fredericq [BE]
Prix Suez
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
Prix Suez
ARC ULg

Available on ORBi :

since 17 March 2010

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