Reference : Elongator - an emerging role in neurological disorders
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/22347
Elongator - an emerging role in neurological disorders
English
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Humbert, Sandrine [ > > ]
Saudou, Frédéric [ > > ]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Jan-2010
Trends in Molecular Medicine
Elsevier Science
16
1-6
Yes (verified by ORBi)
International
1471-4914
Oxford
United Kingdom
[en] Elongator ; tubulin acetylation ; neurological disorders
[en] We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based treatments to correct brain malformations or to prevent the progression of cell death in neurodegenerative disorders, most of these pathologies follow a fatal course. Thus, one major objective is to understand the molecular events that underlie these diseases in order to prevent their onset and/or halt their progression. Converging experimental and clinical evidences obtained by our lab and others prompt us to speculate that Elongator may be commonly targeted in different neurological disorders and as such, should represent a strong candidate for research and development efforts to design drug-based therapies.
GIGA Signal Transduction, GIGA-Neurosciences
FNRS, TELEVIE, ARC, FBC
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/22347

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