Reference : Sciatic Nerve Regeneration through Venous or Nervous Grafts in the Rat
Scientific journals : Article
Human health sciences : Orthopedics, rehabilitation & sports medicine
Human health sciences : Neurology
http://hdl.handle.net/2268/22278
Sciatic Nerve Regeneration through Venous or Nervous Grafts in the Rat
English
Foidart-Dessalle, Marguerite mailto [Université de Liège - ULg > Département des sciences de la motricité > Biomécanique >]
Dubuisson, Annie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurochirurgie >]
Lejeune, André mailto [Université de Liège - ULg > Département Argenco : Secteur MS2F > Hydraulique génér., const. hydraul. et méc. des fluides >]
Severyns, A. [> > > >]
Manassis, Y. [> > > >]
Delree, P. [> > > >]
Crielaard, Jean-Michel mailto [Université de Liège - ULg > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques >]
Bassleer, Roger [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Lejeune, Georges [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Nov-1997
Experimental Neurology
148
1
236-46
Yes (verified by ORBi)
International
0014-4886
[en] This study analyses the interest of isologous venous grafts filled with saline or with Schwann cells versus nerve grafts as guides for regeneration of the sciatic nerve in 35 Wistar rats. Electrophysiological parameters (conduction velocities and distal latencies of motor responses) and the functional index of De Medinacelli were measured several times from 1 month to 1 year after surgery. An histological analysis was performed on 2 control rats and on 3 rats killed 6 or 12 months after surgery: the total number of fibers was counted on a montage photoprint of the whole nerve, and the diameters of axons and the thickness of the myelin sheath were measured on digitized images. With a portion of nerve as guide, the regeneration is faster than with a vein. However, regeneration after 6 months is at least as good with a venous graft filled with Schwann cells, as assessed by electrophysiological, functional, and histological analysis. The addition of Schwann cells in grafted veins allows the nerve to regenerate through longer gaps than previously described (25 vs 15 mm). In order to assess the quality of nerve regeneration, functional, electrophysiological, and histological analysis are complementary.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/22278
10.1006/exnr.1997.6542

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