ORBi: Rigali Sébastien - Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

Reference : Feast or famine: the global regulator DasR links nutrient stress to antibiotic productio...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Microbiology
	To cite this reference:	http://hdl.handle.net/2268/22230

Title :	Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces
Language :	English
Author, co-author :	Rigali, Sébastien [Université de Liège - ULg > Département des sciences de la vie > Département des sciences de la vie >]
	Titgemeyer, Fritz [> >]
	Barends, Sharief [> >]
	Mulder, Suzanne [> >]
	Thomae, Andreas [> >]
	Hopwood, David [> >]
	van Wezel, Gilles [> >]
Publication date :	2008
Journal title :	EMBO Reports
Publisher :	Nature Publishing Group
Volume :	9
Issue/season :	7
Pages :	670-675
Audience :	International
ISSN :	1469-221X
e-ISSN :	1469-3178
City :	London
Country :	United Kingdom
Keywords :	[en] N-acetylglucosamine ; Streptomyces ; antibiotic production ; DasR ; signalling cascade ; secondary metabolite
Abstract :	[en] Members of the soil-dwelling prokaryotic genus Streptomyces produce a wealth of secondary metabolites, including antibiotics and anti-tumour agents. Their formation is intimately coupled with the onset of development, triggered by the nutrient status of the habitat. We propose the first complete signalling cascade from nutrient sensing to development and antibiotic biosynthesis. We show that a high concentration of N-acetylglucosamine - perhaps mimicking the accumulation of N-acetylglucosamine after autolytic degradation of the vegetative mycelium - is a major checkpoint for the onset of secondary metabolism. The response is transmitted to the antibiotic pathway-specific activators via the pleiotropic transcriptional repressor DasR, whose regulon also includes all N-acetylglucosamine-related catabolic genes. The results have led to a new strategy for activating “cryptic” pathways for secondary metabolite biosynthesis, which are abundant in actinomycete genomes, thereby offering new prospects in the fight against multiply drug resistant pathogens and cancers.
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/2268/22230
Other URL :	http://www.nature.com/nrmicro/journal/v6/n8/full/nrmicro1963.html
	http://reflexions.ulg.ac.be/cms/c_18169/rigali-sebastien
Commentary :	This paper has been commented in Nature Microbiology reviews by Sheilagh Molloy. http://www.nature.com/nrmicro/journal/v6/n8/full/nrmicro1963.html

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