ORBi: Quertemont Etienne - Role of acetaldehyde in the discriminative stimulus effects of ethanol

Reference : Role of acetaldehyde in the discriminative stimulus effects of ethanol


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Psychiatry Human health sciences : Pharmacy, pharmacology & toxicology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/2222

Title :	Role of acetaldehyde in the discriminative stimulus effects of ethanol
Language :	English
Author, co-author :	Quertemont, Etienne [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
	Grant, Kathleen A [Wake Forest University > Department of Physiology and Pharmacology > Center for the Neurobehavioral Studies on Alcohol > >]
Publication date :	2002
Journal title :	Alcoholism, Clinical & Experimental Research
Publisher :	Blackwell Publishing
Volume :	26
Issue/season :	6
Pages :	812-817
Audience :	International
ISSN :	0145-6008
e-ISSN :	1530-0277
City :	Oxford
Country :	United Kingdom
Keywords :	[en] Acetaldehyde ; Ethanol ; Drug discrimination ; 3-Amino-1,2,4-Triazole ; rats ; Catalase
Abstract :	[en] Background: Acetaldehyde has been suggested to mediate some of the effects of ethanol. Acetaldehyde can be produced by the enzyme catalase within the brain after ethanol administration. The catalase inhibitor 3-amino-1,2,4-triazole (AT) reduces the production of acetaldehyde, and AT administration can reduce a number of ethanol-induced behavioral effects; this suggests the involvement of acetaldehyde in these behaviors. However, a role for acetaldehyde in mediating the discriminative stimulus effects of ethanol remains unclear. Methods: The contribution of acetaldehyde to the discriminative stimulus effects of ethanol was investigated by use of a two-lever drug discrimination paradigm with food reinforcement. Male Long-Evans rats were trained to discriminate water from either 1.0 or 2.0 g/kg ethanol. Stimulus substitution tests were conducted with ethanol (0 –2.5 g/kg by gavage) and acetaldehyde (0–300 mg/kg intraperitoneally). A cumulative dose-response procedure was then used to investigate the effects of pretreatments with AT (0.5 and 1.0 g/kg intraperitoneally) on ethanol discrimination. Results: Acetaldehyde up to doses that decreased response rates (300 mg/kg) did not substitute for the discriminative stimulus effects of 1.0 or 2.0 g/kg ethanol. In addition, AT pretreatment did not affect the dose-response curves for ethanol discrimination. Conclusions: These results show that exogenous acetaldehyde administration does not produce discriminative stimulus effects that are similar to those of ethanol. Also, pretreatment with the catalase inhibitor did not affect the dose-response curve for ethanol discrimination, and this suggests that endogenously produced acetaldehyde does not contribute to the discriminative stimulus effects of ethanol. Together these results suggest that acetaldehyde does not mediate the discriminative stimulus effects of 1.0 to 2.0 g/kg ethanol.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; National Institute on Alcohol Abuse and Alcoholism
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/2222

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	ACER 2002.pdf		Publisher postprint	461.84 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5