Article (Scientific journals)
Intracranial pressure during liver transplantation for fulminant hepatic failure.
Detry, Olivier; Arkadopoulos, N.; Ting, P. et al.
1999In Transplantation, 67 (5), p. 767-70
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Keywords :
Adult; Brain Edema/etiology; Child; Female; Hepatic Encephalopathy/therapy; Humans; Intracranial Hypertension/etiology; Liver Transplantation/adverse effects; Male; Middle Aged
Abstract :
[en] During orthotopic liver transplantation (OLT) for fulminant hepatic failure (FHF), some patients develop cerebral injury secondary to intracranial hypertension. We monitored intracranial pressure (ICP) and cerebral perfusion pressure (CPP) before and during OLT in 12 FHF patients undergoing transplantation. All four patients who had normal ICP preoperatively maintained normal ICP/CPP throughout OLT. During OLT, four of the eight patients with pretransplant intracranial hypertension had six episodes of ICP increase. These episodes of intracranial hypertension occurred during failing liver dissection (n=3) and graft reperfusion (n=3). At the end of the anhepatic phase, the ICP was lower than the preoperative ICP in all patients, and was below 15 mmHg in all but one patient. These data suggest that in FHF patients who develop intracranial hypertension before OLT, dissection of the native liver and graft reperfusion are associated with a risk of brain injury resulting from intracranial hypertension and cerebral hypoperfusion.
Disciplines :
Gastroenterology & hepatology
Anesthesia & intensive care
Surgery
Author, co-author :
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Arkadopoulos, N.
Ting, P.
Kahaku, E.
Margulies, J.
Arnaout, W.
Colquhoun, S. D.
Rozga, J.
Demetriou, A. A.
Language :
English
Title :
Intracranial pressure during liver transplantation for fulminant hepatic failure.
Publication date :
1999
Journal title :
Transplantation
ISSN :
0041-1337
eISSN :
1534-6080
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
67
Issue :
5
Pages :
767-70
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 September 2009

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