Reference : Intracranial pressure during liver transplantation for fulminant hepatic failure.
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Gastroenterology & hepatology
Human health sciences : Surgery
Intracranial pressure during liver transplantation for fulminant hepatic failure.
Detry, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Arkadopoulos, N. [> > > >]
Ting, P. [> > > >]
Kahaku, E. [> > > >]
Margulies, J. [> > > >]
Arnaout, W. [> > > >]
Colquhoun, S. D. [> > > >]
Rozga, J. [> > > >]
Demetriou, A. A. [> > > >]
Lippincott Williams & Wilkins
Yes (verified by ORBi)
[en] Adult ; Brain Edema/etiology ; Child ; Female ; Hepatic Encephalopathy/therapy ; Humans ; Intracranial Hypertension/etiology ; Liver Transplantation/adverse effects ; Male ; Middle Aged
[en] During orthotopic liver transplantation (OLT) for fulminant hepatic failure (FHF), some patients develop cerebral injury secondary to intracranial hypertension. We monitored intracranial pressure (ICP) and cerebral perfusion pressure (CPP) before and during OLT in 12 FHF patients undergoing transplantation. All four patients who had normal ICP preoperatively maintained normal ICP/CPP throughout OLT. During OLT, four of the eight patients with pretransplant intracranial hypertension had six episodes of ICP increase. These episodes of intracranial hypertension occurred during failing liver dissection (n=3) and graft reperfusion (n=3). At the end of the anhepatic phase, the ICP was lower than the preoperative ICP in all patients, and was below 15 mmHg in all but one patient. These data suggest that in FHF patients who develop intracranial hypertension before OLT, dissection of the native liver and graft reperfusion are associated with a risk of brain injury resulting from intracranial hypertension and cerebral hypoperfusion.
Researchers ; Professionals ; Students ; General public

File(s) associated to this reference

Fulltext file(s):

Restricted access
Transplantation.1999.pdfPublisher postprint3.32 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.