Reference : Intracranial pressure during liver transplantation for fulminant hepatic failure.
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Gastroenterology & hepatology
Human health sciences : Surgery
http://hdl.handle.net/2268/22094
Intracranial pressure during liver transplantation for fulminant hepatic failure.
English
Detry, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Arkadopoulos, N. [> > > >]
Ting, P. [> > > >]
Kahaku, E. [> > > >]
Margulies, J. [> > > >]
Arnaout, W. [> > > >]
Colquhoun, S. D. [> > > >]
Rozga, J. [> > > >]
Demetriou, A. A. [> > > >]
1999
Transplantation
Lippincott Williams & Wilkins
67
5
767-70
Yes (verified by ORBi)
International
0041-1337
1534-6080
Hagerstown
MD
[en] Adult ; Brain Edema/etiology ; Child ; Female ; Hepatic Encephalopathy/therapy ; Humans ; Intracranial Hypertension/etiology ; Liver Transplantation/adverse effects ; Male ; Middle Aged
[en] During orthotopic liver transplantation (OLT) for fulminant hepatic failure (FHF), some patients develop cerebral injury secondary to intracranial hypertension. We monitored intracranial pressure (ICP) and cerebral perfusion pressure (CPP) before and during OLT in 12 FHF patients undergoing transplantation. All four patients who had normal ICP preoperatively maintained normal ICP/CPP throughout OLT. During OLT, four of the eight patients with pretransplant intracranial hypertension had six episodes of ICP increase. These episodes of intracranial hypertension occurred during failing liver dissection (n=3) and graft reperfusion (n=3). At the end of the anhepatic phase, the ICP was lower than the preoperative ICP in all patients, and was below 15 mmHg in all but one patient. These data suggest that in FHF patients who develop intracranial hypertension before OLT, dissection of the native liver and graft reperfusion are associated with a risk of brain injury resulting from intracranial hypertension and cerebral hypoperfusion.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/22094

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