Reference : Differential effect of dietary spermine on alkaline phosphatase activity in jejunum a...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/22012
Differential effect of dietary spermine on alkaline phosphatase activity in jejunum and ileum of unweaned rats
English
Peulen, Olivier mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >]
Gharbi, Myriam [Université de Liège - ULg > Département des sciences de la motricité > Didactique des sciences de la santé >]
Powroznik, Brigitte [> > > >]
Dandrifosse, Guy mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Jul-2004
Biochimie
Editions Scientifiques Medicales Elsevier
86
7
487-493
Yes (verified by ORBi)
International
0300-9084
Paris
[en] alkaline phosphatase ; zymography ; intestine ; weaning ; maturation ; differentiation
[en] Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When it is administered orally to suckling rats it induces the maturation of their spleen, liver, pancreas, and small intestine. We showed that this polyamine modulates differently the activity of alkaline phosphatase in jejunum and ileum in suckling rat. In 14-day-old rat which had received spermine orally for 3 days, once daily, an increase of alkaline phosphatase activity in the jejunum and a decrease of this activity in the ileum was observed. Alkaline phosphatase was located at the bottom of the villus in the control jejunum and in the whole length of the villus in spermine-treated rats. On the contrary, in ileum of controls, this enzyme was present in the whole length of the villus but disappeared in the spermine-treated animals. An enzyme mass shift was observed in the small intestine after spermine administration. Spermine administration did not change the expression of genes coding for alkaline phosphatase, suggesting a post-transcriptional modification. (C) 2004 Elsevier SAS. All rights reserved.
http://hdl.handle.net/2268/22012
10.1016/j.biochi.2004.06.002

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