Reference : Spermine-induced maturation in Wistar rat intestine: A cytokine-dependent mechanism
Scientific journals : Article
Life sciences : Food science
Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/22010
Spermine-induced maturation in Wistar rat intestine: A cytokine-dependent mechanism
English
Peulen, Olivier mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >]
Dandrifosse, Guy mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
May-2004
Journal of Pediatric Gastroenterology and Nutrition
Lippincott Williams & Wilkins
38
5
524-532
Yes (verified by ORBi)
International
0277-2116
Philadelphia
[en] differentiation ; small intestine ; spermine ; suckling ; weaning
[en] Objectives: Polyamines are of great importance in biologic processes such as cell proliferation and differentiation. The ingestion of spermidine or spermine by suckling rats induces the precocious maturation of the small intestine. In a previous article, the authors hypothesized that this phenomenon could be mediated by interleukins. This work was performed to examine the role of IL-1, IL-2, and tumor necrosis factor (TNF)-alpha in the spermine-induced maturation of the small intestine. Methods: Wistar suckling rats were treated with spermine, FR167653 (inhibitor of IL-1beta/TNF-alpha production), IL-1beta/TNF-alpha neutralizing antibodies, lipopolysaccharide, or IL-2. Intestinal disaccharidase-specific activities, polyamine content, and IL-2 plasma concentration were analyzed. Comparisons were made with untreated control animals. Results: Spermine-induced maturation of the small intestine was decreased by FR167653 but not by the neutralizing antibodies. Lipopolysaccharide injection induced an increase in disaccharidase-specific activity. IL-2 induced a decrease of the intestinal lactase-specific activity. Spermine administration led to a similar decrease of lactase activity and to an increase of IL-2 plasma concentration. Conclusions: The authors conclude that IL-1beta and TNF-alpha are involved in the spermine effects on maltase- and sucrase- specific activities and suggest that IL-2 is involved in the spermine-induced decrease of lactase activity. (C) 2004 Lippincott Williams Wilkins.
http://hdl.handle.net/2268/22010

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