Article (Scientific journals)
Allogeneic stem cell transplantation in acute lymphoblastic leukemia patients older than 60 years: A survey from the acute leukemia working party of EBMT
Roth-Guepin, G.; Canaani, J.; Ruggeri, A. et al.
2017In Oncotarget, 8 (68), p. 112972-112979
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Keywords :
Acute lymphoblastic leukemia; Allogeneic hematopoietic cell transplantation; Cytomegalovirus; Elderly; Graft versus host disease
Abstract :
[en] Hematopoietic stem cell transplantation (HSCT) is being increasingly explored as a treatment modality for older patients with acute lymphoblastic leukemia (ALL). Yet, concerns regarding the long term outcome of transplantation in older patients limit the wide spread applicability of this approach. In this analysis we set out to determine the outcome of ALL patients over the age of 60 who underwent reduced intensity HSCT. Herein, we present the experience of the acute leukemia working party (ALWP) of the EBMT in this age group. We analyzed a cohort of 142 patients transplanted in first remission with a median age of 62 (range 60-76 years) and a median follow-up period of 36 months post-transplant. At 3 years, overall survival (OS) and leukemia-free survival were 42% and 35%, respectively. Multivariate analyses identified cytomegalovirus (CMV) donor-recipient matching (CMV D+/R+) to be significantly associated with inferior OS. Patients transplanted from unrelated donors experienced increased grade II-IV acute graft versus host disease compared to those receiving grafts from matched related donors [Hazard ratio (HR) of 3.7, 95% confidence interval (CI), 1.75-7.8; p = 0.0005). Outcome was not impacted by Philadelphia chromosome status. A select subset of older ALL patients will benefit from extended survival and a disease free state following HSCT. © Roth-Guepin et al.
Disciplines :
Hematology
Author, co-author :
Roth-Guepin, G.;  Hematology Department, CHU Brabois, Nancy, France
Canaani, J.;  Hematology Division, Chaim Sheba Medical Center, Tel Aviv University, Israel
Ruggeri, A.;  Acute Leukemia Working Party-EBMT and Department of Hematology and Cell Therapy, Hôpital Saint-Antoine, Paris, France
Labopin, M.;  Acute Leukemia Working Party-EBMT and Department of Hematology and Cell Therapy, Hôpital Saint-Antoine, Paris, France, INSERM UMR, Paris, France, Université Pierre et Marie Curie, Paris, France
Finke, J.;  Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany
Cornelissen, J. J.;  Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Hematology, Rotterdam, Netherlands
Delage, J.;  Service d'Hématologie et d'Oncologie, Hopital Lapeyronie CHU, University Montpellier, Montpellier, France
Stuhler, G.;  Deutsche Klinik für Diagnostik, KMT Zentrum, Wiesbaden, Germany
Rovira, M.;  Hospital Clinic Barcelona, Institute of Hematology and Oncology, Department of Hematology, Spain
Potter, M.;  Institute of Hematology and Oncology, Department of Hematology, London, United Kingdom
Stadler, M.;  Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover, Medical School, Hannover, Germany
Veelken, H.;  Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
Cahn, J. Y.;  Department of Hematology, University Hospital, Grenoble, France
Collin, M.;  Newcastle University, Adult HSCT unit, Northern Centre for Bone Marrow Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Giebel, S.;  Department of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
Nagler, A.;  Hematology Division, Chaim Sheba Medical Center, Tel Aviv University, Israel, Acute Leukemia Working Party-EBMT and Department of Hematology and Cell Therapy, Hôpital Saint-Antoine, Paris, France
Mohty, M.;  Acute Leukemia Working Party-EBMT and Department of Hematology and Cell Therapy, Hôpital Saint-Antoine, Paris, France, INSERM UMR, Paris, France, Université Pierre et Marie Curie, Paris, France
More authors (8 more) Less
Language :
English
Title :
Allogeneic stem cell transplantation in acute lymphoblastic leukemia patients older than 60 years: A survey from the acute leukemia working party of EBMT
Publication date :
2017
Journal title :
Oncotarget
eISSN :
1949-2553
Publisher :
Impact Journals LLC
Volume :
8
Issue :
68
Pages :
112972-112979
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 January 2018

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