Mohawk, J.A., Green, C.B., Takahashi, J.S., Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 35 (2012), 445–462.
Aryal, R.P., Kwak, P.B., Tamayo, A.G., Gebert, M., Chiu, P.L., Walz, T., et al. Macromolecular assemblies of the mammalian circadian clock. Mol Cell 67:5 (2017), 770–782 e6.
von Schantz, M., Jenkins, A., Archer, S.N., Evolutionary history of the vertebrate period genes. J Mol Evol 62:6 (2006), 701–707.
Bae, K., Jin, X., Maywood, E.S., Hastings, M.H., Reppert, S.M., Weaver, D.R., Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30:2 (2001), 525–536.
Shearman, L.P., Jin, X., Lee, C., Reppert, S.M., Weaver, D.R., Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol 20:17 (2000), 6269–6275.
Pendergast, J.S., Niswender, K.D., Yamazaki, S., Tissue-specific function of Period3 in circadian rhythmicity. PLoS One, 7(1), 2012, e30254.
Takumi, T., Taguchi, K., Miyake, S., Sakakida, Y., Takashima, N., Matsubara, C., et al. A light-independent oscillatory gene mPer3 in mouse SCN and OVLT. Embo J 17:16 (1998), 4753–4759.
Zylka, M.J., Shearman, L.P., Weaver, D.R., Reppert, S.M., Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron 20:6 (1998), 1103–1110.
Winrow, C.J., Tanis, K.Q., Rigby, A.M., Taylor, R.R., Serikawa, K., McWhorter, M., et al. Refined anatomical isolation of functional sleep circuits exhibits distinctive regional and circadian gene transcriptional profiles. Brain Res 1271 (2009), 1–17.
Pendergast, J.S., Friday, R.C., Yamazaki, S., Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis. PLoS One, 5(1), 2010, e8552.
Ramanathan, C., Xu, H., Khan, S.K., Shen, Y., Gitis, P.J., Welsh, D.K., et al. Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models. PLoS Genet, 10(4), 2014, e1004244.
Tosini, G., Davidson, A.J., Fukuhara, C., Kasamatsu, M., Castanon-Cervantes, O., Localization of a circadian clock in mammalian photoreceptors. FASEB J 21:14 (2007), 3866–3871.
Simonneaux, V., Poirel, V.J., Garidou, M.L., Nguyen, D., Diaz-Rodriguez, E., Pevet, P., Daily rhythm and regulation of clock gene expression in the rat pineal gland. Brain Res Mol Brain Res 120:2 (2004), 164–172.
van der Veen, D.R., Archer, S.N., Light-dependent behavioral phenotypes in PER3-deficient mice. J Biol Rhythms 25:1 (2010), 3–8.
Chellappa, S.L., Viola, A.U., Schmidt, C., Bachmann, V., Gabel, V., Maire, M., et al. Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3. J Clin Endocrinol Metab 97:3 (2012), E433–E437.
Vandewalle, G., Archer, S.N., Wuillaume, C., Balteau, E., Degueldre, C., Luxen, A., et al. Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis. J Biol Rhythms 26:3 (2011), 249–259.
Otway, D.T., Mantele, S., Bretschneider, S., Wright, J., Trayhurn, P., Skene, D.J., et al. Rhythmic diurnal gene expression in human adipose tissue from individuals who are lean, overweight, and type 2 diabetic. Diabetes 60:5 (2011), 1577–1581.
Archer, S.N., Viola, A.U., Kyriakopoulou, V., Schantz, Mv, Dijk, D.J., Inter-individual differences in habitual sleep timing and entrianed phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. Sleep 31:5 (2008), 608–617.
Kusanagi, H., Hida, A., Satoh, K., Echizenya, M., Shimizu, T., Pendergast, J.S., et al. Expression profiles of 10 circadian clock genes in human peripheral blood mononuclear cells. Neurosci Res 61:2 (2008), 136–142.
Akashi, M., Soma, H., Yamamoto, T., Tsugitomi, A., Yamashita, S., Yamamoto, T., et al. Noninvasive method for assessing the human circadian clock using hair follicle cells. Proc Natl Acad Sci U S A 107:35 (2010), 15643–15648.
Sporl, F., Korge, S., Jurchott, K., Wunderskirchner, M., Schellenberg, K., Heins, S., et al. Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc Natl Acad Sci U S A 109:27 (2012), 10903–10908.
Li, J.Z., Bunney, B.G., Meng, F., Hagenauer, M.H., Walsh, D.M., Vawter, M.P., et al. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci U S A 110:24 (2013), 9950–9955.
Lim, A.S., Srivastava, G.P., Yu, L., Chibnik, L.B., Xu, J., Buchman, A.S., et al. 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex. PLoS Genet, 10(11), 2014, e1004792.
Chen, C.Y., Logan, R.W., Ma, T., Lewis, D.A., Tseng, G.C., Sibille, E., et al. Effects of aging on circadian patterns of gene expression in the human prefrontal cortex. Proc Natl Acad Sci U S A 113:1 (2016), 206–211.
Hughes, M.E., DiTacchio, L., Hayes, K.R., Vollmers, C., Pulivarthy, S., Baggs, J.E., et al. Harmonics of circadian gene transcription in mammals. PLoS Genet, 5(4), 2009, e1000442.
Moller-Levet, C.S., Archer, S.N., Bucca, G., Laing, E.E., Slak, A., Kabiljo, R., et al. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci U S A 110:12 (2013), E1132–E1141.
Archer, S.N., Laing, E.E., Moller-Levet, C.S., van der Veen, D.R., Bucca, G., Lazar, A.S., et al. Mistimed sleep disrupts circadian regulation of the human transcriptome. Proc Natl Acad Sci U S A 111:6 (2014), E682–E691.
Arnardottir, E.S., Nikonova, E.V., Shockley, K.R., Podtelezhnikov, A.A., Anafi, R.C., Tanis, K.Q., et al. Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37:10 (2014), 1589–1600.
Anafi, R.C., Francey, L.J., Hogenesch, J.B., Kim, J., CYCLOPS reveals human transcriptional rhythms in health and disease. Proc Natl Acad Sci U S A 114:20 (2017), 5312–5317.
Laing, E.E., Johnston, J.D., Moller-Levet, C.S., Bucca, G., Smith, C.P., Dijk, D.J., et al. Exploiting human and mouse transcriptomic data: identification of circadian genes and pathways influencing health. BioEssays 37:5 (2015), 544–556.
Matsumura, R., Akashi, M., Multiple circadian transcriptional elements cooperatively regulate cell-autonomous transcriptional oscillation of Period3, a mammalian clock gene. J Biol Chem 292:39 (2017), 16081–16092.
Ebisawa, T., Uchiyama, M., Kajimura, N., Mishima, K., Kamei, Y., Katoh, M., et al. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep 2:4 (2001), 342–346.
von Schantz, M., Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters. J Genet 87:5 (2008), 513–519.
Lee, C., Weaver, D.R., Reppert, S.M., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol 24:2 (2004), 584–594.
Archer, S.N., Robilliard, D., Skene, D.J., Smits, M.G., Williams, A., Arendt, J., et al. A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 26 (2003), 413–415.
Lee, H.M., Chen, R., Kim, H., Etchegaray, J.P., Weaver, D.R., Lee, C., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A 108:39 (2011), 16451–16456.
Toh, K.L., Jones, C.R., He, Y., Eide, E.J., Hinz, W.A., Virshup, D.M., et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291:5506 (2001), 1040–1043.
Jenkins, A., Archer, S.N., von Schantz, M., Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene period3. J Biol Rhythms 20:5 (2005), 470–472.
Sabino, F.C., Ribeiro, A.O., Tufik, S., Torres, L.B., Oliveira, J.A., Mello, L.E., et al. Evolutionary history of the PER3 variable number of tandem repeats (VNTR): idiosyncratic aspect of primate molecular circadian clock. PLoS One, 9(9), 2014, e107198.
Pereira, D.S., Tufik, S., Louzada, F.M., Benedito-Silva, A.A., Lopez, A.R., Lemos, N.A., et al. Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it?. Sleep 28:1 (2005), 29–32.
Jones, K.H., Ellis, J., von Schantz, M., Skene, D.J., Dijk, D.J., Archer, S.N., Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities. J Sleep Res 16:1 (2007), 12–16.
Kunorozva, L., Stephenson, K.J., Rae, D.E., Roden, L.C., Chronotype and PERIOD3 variable number tandem repeat polymorphism in individual sports athletes. Chronobiol Int 29:8 (2012), 1004–1010.
Liberman, A.R., Kwon, S.B., Vu, H.T., Filipowicz, A., Ay, A., Ingram, K.K., Circadian clock model supports molecular link between PER3 and human anxiety. Sci Rep, 7(1), 2017, 9893.
Lazar, A.S., Slak, A., Lo, J.C., Santhi, N., von Schantz, M., Archer, S.N., et al. Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study. Chronobiol Int 29:2 (2012), 131–146.
Ruiz-Lozano, T., Vidal, J., de Hollanda, A., Canteras, M., Garaulet, M., Izquierdo-Pulido, M., Evening chronotype associates with obesity in severely obese subjects: interaction with CLOCK 3111T/C. Int J Obes (Lond) 40:10 (2016), 1550–1557.
Archer, S.N., Carpen, J.D., Gibson, M., Lim, G.H., Johnston, J.D., Skene, D.J., et al. Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder. Sleep 33:5 (2010), 695–701.
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppa, T., et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 28:4 (2003), 734–739.
Ojeda, D.A., Perea, C.S., Nino, C.L., Gutierrez, R.M., Lopez-Leon, S., Arboleda, H., et al. A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales. Neurosci Lett 553 (2013), 52–56.
Hida, A., Kitamura, S., Katayose, Y., Kato, M., Ono, H., Kadotani, H., et al. Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder. Sci Rep, 4, 2014, 6309.
Shi, S.Q., White, M.J., Borsetti, H.M., Pendergast, J.S., Hida, A., Ciarleglio, C.M., et al. Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks. Transl Psychiatry, 6, 2016, e748.
Turco, M., Biscontin, A., Corrias, M., Caccin, L., Bano, M., Chiaromanni, F., et al. Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3. Sci Rep, 7(1), 2017, 6967.
Goel, N., Banks, S., Mignot, E., Dinges, D.F., PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS One, 4(6), 2009, e5874.
Barclay, N.L., Eley, T.C., Mill, J., Wong, C.C., Zavos, H.M., Archer, S.N., et al. Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. Am J Med Genet B Neuropsychiatr Genet 156B:6 (2011), 681–690.
Perea, C.S., Nino, C.L., Lopez-Leon, S., Gutierrez, R., Ojeda, D., Arboleda, H., et al. Study of a functional polymorphism in the PER3 gene and diurnal preference in a Colombian sample. Open Neurol J 8 (2014), 7–10.
Henst, R.H., Jaspers, R.T., Roden, L.C., Rae, D.E., A chronotype comparison of South African and Dutch marathon runners: the role of scheduled race start times and effects on performance. Chronobiol Int 32:6 (2015), 858–868.
Kunorozva, L., Rae, D.E., Roden, L.C., Chronotype distribution in professional rugby players: evidence for the environment hypothesis?. Chronobiol Int, 2017, 1–11.
Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J.Y., Hinds, D.A., GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person. Nat Commun, 7, 2016, 10448.
Lane, J.M., Vlasac, I., Anderson, S.G., Kyle, S.D., Dixon, W.G., Bechtold, D.A., et al. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun, 7, 2016, 10889.
Mansour, H.A., Wood, J., Chowdari, K.V., Tumuluru, D., Bamne, M., Monk, T.H., et al. Associations between period 3 gene polymorphisms and sleep-/chronotype-related variables in patients with late-life insomnia. Chronobiol Int 34:5 (2017), 624–631.
Merikanto, I., Kronholm, E., Peltonen, M., Laatikainen, T., Vartiainen, E., Partonen, T., Circadian preference links to depression in general adult population. J Affect Disord 188 (2015), 143–148.
Dijk, D.J., Archer, S.N., PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med Rev 14:3 (2010), 151–160.
Viola, A.U., Chellappa, S.L., Archer, S.N., Pugin, F., Gotz, T., Dijk, D.J., et al. Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism. Neurobiol Aging, 33(5), 2012 1010 e17–27.
Chang, A.M., Bjonnes, A.C., Aeschbach, D., Buxton, O.M., Gooley, J.J., Anderson, C., et al. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiology Int 33:5 (2016), 561–573.
Franken, P., A role for clock genes in sleep homeostasis. Curr Opin Neurobiol 23:5 (2013), 864–872.
Hasan, S., van der Veen, D.R., Winsky-Sommerer, R., Hogben, A., Laing, E.E., Koentgen, F., et al. A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism. FASEB J 28:6 (2014), 2441–2454.
Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., et al. Homer1a is a core brain molecular correlate of sleep loss. Proc Natl Acad Sci U S A 104:50 (2007), 20090–20095.
Diering, G.H., Nirujogi, R.S., Roth, R.H., Worley, P.F., Pandey, A., Huganir, R.L., Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science 355:6324 (2017), 511–515.
Groeger, J.A., Viola, A.U., Lo, J.C.Y., von Schantz, M., Archer, S.N., Dijk, D.J., Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism. Sleep 31:8 (2008), 1159–1167.
Lo, J.C., Groeger, J.A., Santhi, N., Arbon, E.L., Lazar, A.S., Hasan, S., et al. Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase. PLoS One, 7(9), 2012, e45987.
Rupp, T.L., Wesensten, N.J., Newman, R., Balkin, T.J., PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction. J Sleep Res 22:2 (2013), 160–165.
Blatter, K., Cajochen, C., Circadian rhythms in cognitive performance: methodological constraints, protocols, theoretical underpinnings. Physiol Behav 90:2–3 (2007), 196–208.
Tucker, A.M., Whitney, P., Belenky, G., Hinson, J.M., Van Dongen, H.P., Effects of sleep deprivation on dissociated components of executive functioning. Sleep 33:1 (2010), 47–57.
Lim, J., Dinges, D.F., Sleep deprivation and vigilant attention. Ann N Y Acad Sci 1129 (2008), 305–322.
Santhi, N., Lazar, A.S., McCabe, P.J., Lo, J.C., Groeger, J.A., Dijk, D.J., Sex differences in the circadian regulation of sleep and waking cognition in humans. Proc Natl Acad Sci U S A 113:19 (2016), E2730–E2739.
Vandewalle, G., Archer, S.N., Wuillaume, C., Balteau, E., Degueldre, C., Luxen, A., et al. Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype. J Neurosci 29:25 (2009), 7948–7956.
Chee, M.W., Choo, W.C., Functional imaging of working memory after 24 hr of total sleep deprivation. J Neurosci 24:19 (2004), 4560–4567.
Maire, M., Reichert, C.F., Gabel, V., Viola, A.U., Strobel, W., Krebs, J., et al. Sleep ability mediates individual differences in the vulnerability to sleep loss: evidence from a PER3 polymorphism. Cortex 52 (2014), 47–59.
Maire, M., Reichert, C.F., Gabel, V., Viola, A.U., Krebs, J., Strobel, W., et al. Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation. Front Behav Neurosci, 8, 2014, 59.
Maire, M., Reichert, C.F., Gabel, V., Viola, A.U., Phillips, C., Krebs, J., et al. Fighting sleep at night: brain correlates and vulnerability to sleep loss. Ann Neurol 78:2 (2015), 235–247.
Zhu, Y., Xi, Y., Fei, N., Liu, Y., Zhang, X., Liu, L., et al. Dynamics of cerebral responses to sustained attention performance during one night of sleep deprivation. J Sleep Res, 2017, 10.1111/jsr.12582.
Rodrigue, K.M., Raz, N., Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults. J Neurosci 24:4 (2004), 956–963.
Muto, V., Jaspar, M., Meyer, C., Kusse, C., Chellappa, S.L., Degueldre, C., et al. Local modulation of human brain responses by circadian rhythmicity and sleep debt. Science 353:6300 (2016), 687–690.
Schmidt, T.M., Chen, S.K., Hattar, S., Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions. Trends Neurosci 34:11 (2011), 572–580.
Pereira, D.S., van der Veen, D.R., Goncalves, B.S., Tufik, S., von Schantz, M., Archer, S.N., et al. The effect of different photoperiods in circadian rhythms of per3 knockout mice. BioMed Res Int, 2014, 2014, 170795.
Burgess, H.J., Eastman, C.I., Short nights reduce light-induced circadian phase delays in humans. Sleep 29:1 (2006), 25–30.
Zhang, L., Hirano, A., Hsu, P.K., Jones, C.R., Sakai, N., Okuro, M., et al. A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A 113:11 (2016), E1536–E1544.
Lamont, E.W., Legault-Coutu, D., Cermakian, N., Boivin, D.B., The role of circadian clock genes in mental disorders. Dialogues Clin Neurosci 9:3 (2007), 333–342.
Maglione, J.E., Nievergelt, C.M., Parimi, N., Evans, D.S., Ancoli-Israel, S., Stone, K.L., et al. Associations of PER3 and RORA circadian gene polymorphisms and depressive symptoms in older adults. Am J Geriatr Psychiatry 23:10 (2015), 1075–1087.
Dmitrzak-Weglarz, M.P., Pawlak, J.M., Maciukiewicz, M., Moczko, J., Wilkosc, M., Leszczynska-Rodziewicz, A., et al. Clock gene variants differentiate mood disorders. Mol Biol Rep 42:1 (2015), 277–288.
Mansour, H.A., Wood, J., Logue, T., Chowdari, K.V., Dayal, M., Kupfer, D.J., et al. Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav 5:2 (2006), 150–157.
Benedetti, F., Dallaspezia, S., Colombo, C., Pirovano, A., Marino, E., Smeraldi, E., A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci Lett 445:2 (2008), 184–187.
Nievergelt, C.M., Kripke, D.F., Barrett, T.B., Burg, E., Remick, R.A., Sadovnick, A.D., et al. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 141:3 (2006), 234–241.
Karthikeyan, R., Marimuthu, G., Ramasubramanian, C., Arunachal, G., BaHammam, A.S., Spence, D.W., et al. Association of Per3 length polymorphism with bipolar I disorder and schizophrenia. Neuropsychiatr Dis Treat 10 (2014), 2325–2330.
Dallaspezia, S., Locatelli, C., Lorenzi, C., Pirovano, A., Colombo, C., Benedetti, F., Sleep homeostatic pressure and PER3 VNTR gene polymorphism influence antidepressant response to sleep deprivation in bipolar depression. J Affect Disord 192 (2016), 64–69.
Martynhak, B.J., Hogben, A.L., Zanos, P., Georgiou, P., Andreatini, R., Kitchen, I., et al. Transient anhedonia phenotype and altered circadian timing of behaviour during night-time dim light exposure in Per3-/- mice, but not wildtype mice. Sci Rep, 7, 2017, 40399.
Dumont, M., Beaulieu, C., Light exposure in the natural environment: relevance to mood and sleep disorders. Sleep Med 8:6 (2007), 557–565.
Bollettini, I., Melloni, E.M., Aggio, V., Poletti, S., Lorenzi, C., Pirovano, A., et al. Clock genes associate with white matter integrity in depressed bipolar patients. Chronobiol Int 34:2 (2017), 212–224.
Zou, Y., Liao, G., Liu, Y., Wang, Y., Yang, Z., Lin, Y., et al. Association of the 54-nucleotide repeat polymorphism of hPer3 with heroin dependence in Han Chinese population. Genes Brain Behav 7:1 (2008), 26–30.
Brower, K.J., Wojnar, M., Sliwerska, E., Armitage, R., Burmeister, M., PER3 polymorphism and insomnia severity in alcohol dependence. Sleep 35:4 (2012), 571–577.
Wang, X., Mozhui, K., Li, Z., Mulligan, M.K., Ingels, J.F., Zhou, X., et al. A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Transl Psychiatry, 2, 2012 e73.
Viena, T.D., Gobin, C.M., Fins, A.I., Craddock, T.J., Tartar, A., Tartar, J.L., A PER3 polymorphism interacts with sleep duration to influence transient mood states in women. J Circadian Rhythms, 14, 2016, 3.
Feillet, C., van der Horst, G.T., Levi, F., Rand, D.A., Delaunay, F., Coupling between the circadian clock and cell cycle oscillators: implication for healthy cells and malignant growth. Front Neurol, 6, 2015, 96.
Karantanos, T., Theodoropoulos, G., Gazouli, M., Vaiopoulou, A., Karantanou, C., Lymberi, M., et al. Expression of clock genes in patients with colorectal cancer. Int J Biol Markers 28:3 (2013), 280–285.
Karantanos, T., Theodoropoulos, G., Pektasides, D., Gazouli, M., Clock genes: their role in colorectal cancer. World J Gastroenterol 20:8 (2014), 1986–1992.
Zhang, F., Sun, H., Zhang, S., Yang, X., Zhang, G., Su, T., Overexpression of PER3 inhibits self-renewal Capability and chemoresistance of colorectal cancer stem-like cells via inhibition of Notch and beta-Catenin signaling. Oncol Res 25:5 (2017), 709–719.
Wang, X., Yan, D., Teng, M., Fan, J., Zhou, C., Li, D., et al. Reduced expression of PER3 is associated with incidence and development of colon cancer. Ann Surg Oncol 19:9 (2012), 3081–3088.
Hong, Z., Feng, Z., Sai, Z., Tao, S., PER3, a novel target of miR-103, plays a suppressive role in colorectal cancer in vitro. BMB Rep 47:9 (2014), 500–505.
Yang, M.Y., Lin, P.M., Hsiao, H.H., Hsu, J.F., Lin, H.Y., Hsu, C.M., et al. Up-regulation of PER3 expression is correlated with better clinical outcome in acute leukemia. Anticancer Res 35:12 (2015), 6615–6622.
Hsu, C.M., Lin, S.F., Lu, C.T., Lin, P.M., Yang, M.Y., Altered expression of circadian clock genes in head and neck squamous cell carcinoma. Tumour Biol 33:1 (2012), 149–155.
Liu, B., Xu, K., Jiang, Y., Li, X., Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. Int J Clin Exp Pathol 7:11 (2014), 7863–7871.
Cadenas, C., van de Sandt, L., Edlund, K., Lohr, M., Hellwig, B., Marchan, R., et al. Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle 13:20 (2014), 3282–3291.
Zhu, Y., Stevens, R.G., Hoffman, A.E., Fitzgerald, L.M., Kwon, E.M., Ostrander, E.A., et al. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Cancer Res 69:24 (2009), 9315–9322.
Zienolddiny, S., Haugen, A., Lie, J.A., Kjuus, H., Anmarkrud, K.H., Kjaerheim, K., Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts. Breast Cancer Res, 15(4), 2013, R53.
Couto, P., Miranda, D., Vieira, R., Vilhena, A., De Marco, L., Bastos-Rodrigues, L., Association between CLOCK, PER3 and CCRN4L with nonsmall cell lung cancer in Brazilian patients. Mol Med Rep 10:1 (2014), 435–440.
Qu, F., Qiao, Q., Wang, N., Ji, G., Zhao, H., He, L., et al. Genetic polymorphisms in circadian negative feedback regulation genes predict overall survival and response to chemotherapy in gastric cancer patients. Sci Rep, 6, 2016, 22424.
Zhang, Z., Ma, F., Zhou, F., Chen, Y., Wang, X., Zhang, H., et al. Functional polymorphisms of circadian negative feedback regulation genes are associated with clinical outcome in hepatocellular carcinoma patients receiving radical resection. Med Oncol, 31(12), 2014, 179.
Gutierrez-Monreal, M.A., Villela, L., Baltazar, S., Perfecto-Avalos, Y., Cardineau, G.A., Scott, S.P., A PER3 polymorphism is associated with better overall survival in diffuse large B-cell lymphoma in Mexican population. Cancer Biomark 15:5 (2015), 699–705.
Alexander, M., Burch, J.B., Steck, S.E., Chen, C.F., Hurley, T.G., Cavicchia, P., et al. Case-control study of the PERIOD3 clock gene length polymorphism and colorectal adenoma formation. Oncol Rep 33:2 (2015), 935–941.
Koike, N., Yoo, S.H., Huang, H.C., Kumar, V., Lee, C., Kim, T.K., et al. Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 338:6105 (2012), 349–354.
Bhatti, P., Zhang, Y., Song, X., Makar, K.W., Sather, C.L., Kelsey, K.T., et al. Nightshift work and genome-wide DNA methylation. Chronobiol Int 32:1 (2015), 103–112.
Bracci, M., Manzella, N., Copertaro, A., Staffolani, S., Strafella, E., Barbaresi, M., et al. Rotating-shift nurses after a day off: peripheral clock gene expression, urinary melatonin, and serum 17-beta-estradiol levels. Scand J Work Environ Health 40:3 (2014), 295–304.
Alexander, M., Burch, J.B., Steck, S.E., Chen, C.F., Hurley, T.G., Cavicchia, P., et al. Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis 32:2 (2017), 183–192.
Neumann, O., Kesselmeier, M., Geffers, R., Pellegrino, R., Radlwimmer, B., Hoffmann, K., et al. Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors. Hepatology 56:5 (2012), 1817–1827.
Samblas, M., Milagro, F.I., Mansego, M.L., Marti, A., Martinez, J.A., Members G, PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis. Pediatr Obes, 2017, 10.1111/ijpo.12224.
Nadkarni, N.A., Weale, M.E., von Schantz, M., Thomas, Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system. J Biol Rhythms 20:6 (2005), 490–499.