Article (Scientific journals)
Neutrophil-Derived Interleukin 16 in Premetastatic Lungs Promotes Breast Tumor Cell Seeding.
Donati, Kim; Sepult, Christelle; Rocks, Natacha et al.
2017In Cancer Growth and Metastasis, 10, p. 1179064417738513
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Keywords :
IL-16; Tumor microenvironment; breast cancer; lungs; metastasis; neutrophils
Abstract :
[en] The premetastatic niche in distant organs prior to metastatic cell arrival emerged as an important step in the metastatic cascade. However, molecular mechanisms underlying this process are still poorly understood. In particular, whether neutrophil recruitment at a premetastatic stage promotes or inhibits metastatic cell seeding has to be clarified. We aimed at unraveling how neutrophil infiltration in lung parenchyma induced by the distant primary tumor influences the establishment of lung metastasis. Elevated neutrophil counts and IL-16 levels were found in premetastatic lungs in a syngenic mouse model using 4T1 tumor cells. 4T1 cell-derived soluble factors stimulated IL-16 secretion by neutrophils. The functional contribution of IL-16 is supported by metastasis burden reduction in lungs observed on instillation of an IL-16 neutralizing antibody. Moreover, IL-16 promotes in vitro 4T1 cell adhesiveness, invasiveness, and migration. In conclusion, at a premetastatic stage, neutrophil-derived IL-16 favors tumor cell engraftment in lung parenchyma.
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
Donati, Kim ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Sepult, Christelle ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Rocks, Natacha ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Blacher, Silvia ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Gérard, Catherine ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Cataldo, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Language :
English
Title :
Neutrophil-Derived Interleukin 16 in Premetastatic Lungs Promotes Breast Tumor Cell Seeding.
Publication date :
2017
Journal title :
Cancer Growth and Metastasis
eISSN :
1179-0644
Publisher :
SAGE Publications, Thousand Oaks, United States - California
Volume :
10
Pages :
1179064417738513
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 December 2017

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