Article (Scientific journals)
Visual evoked potentials in subgroups of migraine with aura patients
Coppola, G.; Bracaglia, M.; Di Lenola, D. et al.
2015In Journal of Headache and Pain, 16 (1)
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Keywords :
Complex aura; Cortical excitability; Habituation; Migraine with aura; Visual aura; Visual evoked potentials; Article; Adult; Analysis of Variance; Evoked Potentials, Visual; Female; Humans; Male; Middle Aged; Regression Analysis; Visual Cortex; Young Adult
Abstract :
[en] Background: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both. Few studies have searched for possible pathophysiological differences between these two subgroups of patients. Methods: Methods - Forty-seven migraine with aura patients were subdivided in a subgroup with exclusively visual auras (MA, N = 27) and another with complex neurological auras (MA+, N = 20). We recorded pattern-reversal visual evoked potentials (VEP: 15 min of arc cheques, 3.1 reversal per second, 600 sweeps) and measured amplitude and habituation (slope of the linear regression line of amplitude changes from the 1st to 6th block of 100 sweeps) for the N1-P1 and P1-N2 components in patients and, for comparison, in 30 healthy volunteers (HV) of similar age and gender distribution. Results: VEP N1-P1 habituation, i.e. amplitude decrement between 1st and 6th block, which was obvious in most HV (mean slope −0.50), was deficient in both MA (slope +0.01, p = 0.0001) and MA+ (−0.0049, p = 0.001) patients. However, VEP N1-P1 amplitudes across blocks were normal in MA patients, while they were significantly greater in MA+ patients than in HVs. Conclusions: Our findings suggest that in migraine with aura patients different aura phenotypes may be underpinned by different pathophysiological mechanisms. Pre-activation cortical excitability could be higher in patients with complex neurological auras than in those having pure visual auras or in healthy volunteers. © 2015, Coppola et al.
Disciplines :
Neurology
Author, co-author :
Coppola, G.;  G.B. Bietti Foundation-IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Via Livenza 3, Rome, Italy
Bracaglia, M.;  Department of Medical and Surgical Sciences and Biotechnologies, “Sapienza” University of Rome Polo Pontino, Latina, Italy
Di Lenola, D.;  Department of Medical and Surgical Sciences and Biotechnologies, “Sapienza” University of Rome Polo Pontino, Latina, Italy
Di Lorenzo, C.;  Fondazione Don Gnocchi, Milan, Italy
Tavares Alvares Serrão, Margarida ;  Université de Liège - ULiège > Faculté d'Architecture > Architecture Site Outremeuse
Parisi, V.;  G.B. Bietti Foundation-IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Via Livenza 3, Rome, Italy
Di Renzo, A.;  G.B. Bietti Foundation-IRCCS, Department of Neurophysiology of Vision and Neurophthalmology, Via Livenza 3, Rome, Italy
Martelli, F.;  Istituto Superiore di Sanità, Dipartimento Tecnologie e Salute, Rome, Italy
Fadda, A.;  Istituto Superiore di Sanità, Dipartimento Tecnologie e Salute, Rome, Italy
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Pierelli, F.;  Department of Medical and Surgical Sciences and Biotechnologies, “Sapienza” University of Rome Polo Pontino, Latina, Italy, IRCCS-Neuromed, Pozzilli, IS, Italy
Language :
English
Title :
Visual evoked potentials in subgroups of migraine with aura patients
Publication date :
2015
Journal title :
Journal of Headache and Pain
ISSN :
1129-2369
eISSN :
1129-2377
Publisher :
Springer-Verlag Italia s.r.l.
Volume :
16
Issue :
1
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 December 2017

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