Replacement of proline 174 with glutamic acid in GES-1 enzyme improve the flexibility of Ω-loop leading to an increase of catalytic efficiency towards carbapenems
Mercuri, Paola ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Aschi, M.
Segatore, B
Galleni, Moreno ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Celenza, G
Amicosante, Gianfranco
Language :
English
Title :
Replacement of proline 174 with glutamic acid in GES-1 enzyme improve the flexibility of Ω-loop leading to an increase of catalytic efficiency towards carbapenems