Article (Scientific journals)
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle
REIS MOTA, Rodrigo; Guimarães, S.E.F; Fortes, M.R.S. et al.
2017In Journal of Animal Breeding and Genetics, 134 (6), p. 484–492
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Keywords :
beef cattle; gene function; single-step
Abstract :
[en] We performed a genome-wide mapping for the age at first calving (AFC) with the goal of annotating candidate genes that regulate fertility in Nellore cattle. Phenotypic data from 762 cows and 777k SNP genotypes from 2,992 bulls and cows were used. Single nucleotide polymorphism (SNP) effects based on the single- step GBLUP methodology were blocked into adjacent windows of 1 Megabase (Mb) to explain the genetic variance. SNP windows explaining more than 0.40% of the AFC genetic variance were identified on chromosomes 2, 8, 9, 14, 16 and 17. From these windows, we identified 123 coding protein genes that were used to build gene networks. From the association study and derived gene networks, putative candidate genes (e.g., PAPPA, PREP, FER1L6, TPR, NMNAT1, ACAD10, PCMTD1, CRH, OPKR1, NPBWR1 and NCOA2) and transcription factors (TF) (STAT1, STAT3, RELA, E2F1 and EGR1) were strongly associated with female fertility (e.g., negative regulation of luteinizing hormone secretion, folliculogenesis and establishment of uterine receptivity). Evidence suggests that AFC inheritance is complex and controlled by multiple loci across the genome. As several windows explaining higher proportion of the genetic variance were identified on chromosome 14, further studies investigating the interaction across haplotypes to better understand the molecular architecture behind AFC in Nellore cattle should be undertaken.
Disciplines :
Animal production & animal husbandry
Author, co-author :
REIS MOTA, Rodrigo ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Ingénierie des productions animales et nutrition
Guimarães, S.E.F
Fortes, M.R.S.
Hayes, B.
Fonseca e Silva, Fabyano
Verardo, V. V.
Kelly, M. J.
de Campos, C. F.
Guimarães, J. D.
Wenceslau, R. R.
Penitente-Filho, J. M.
Garcia, J. F.
Moore, S.
More authors (3 more) Less
Language :
English
Title :
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle
Publication date :
22 November 2017
Journal title :
Journal of Animal Breeding and Genetics
ISSN :
0931-2668
eISSN :
1439-0388
Publisher :
Blackwell Publishing, Berlin, Germany
Volume :
134
Issue :
6
Pages :
484–492
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 November 2017

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