Article (Scientific journals)
Correlation between habituation of visual-evoked potentials and magnetophosphene thresholds in migraine: A case-control study
Ambrosini, A.; Iezzi, E.; Perrotta, A. et al.
2016In Cephalalgia, 36 (3), p. 258-264
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Keywords :
Migraine; Article; Adolescent; Adult; Case-Control Studies; Electroencephalography; Evoked Potentials, Visual; Female; Habituation, Psychophysiologic; Humans; Male; Middle Aged; Migraine Disorders; Phosphenes; Photic Stimulation; Transcranial Magnetic Stimulation; Young Adult
Abstract :
[en] Introduction In migraine most studies report an interictal deficit of habituation of visual-evoked potentials (VEP-hab) and reduced thresholds for phosphene induction (PT) by transcranial magnetic stimulation (TMS). We searched for a possible correlation between VEP-hab and PT in migraine patients and healthy controls to test whether they reflect the same pathophysiological abnormality. Methods We assessed PT and VEP-hab measured as the percentage change of N1/P1 amplitude over six blocks of 100 responses in 15 healthy volunteers (HV) and in 13 episodic migraineurs without aura (MO) between attacks. Results were compared using Mann-Whitney U test. Interrelationships were examined using Spearman's correlation. Results In MO patients VEP-hab was reduced compared to HV (p = 0.001), while PT were not significantly different between HV and MO. There was no correlation between PT and VEP-hab in either group of participants. Conclusions We confirm that in interictal migraine VEP habituation is deficient, but magnetophosphene threshold normal. VEP-hab and PT were not correlated with each other in healthy controls or in migraineurs. This finding suggests that they index different facets of cortical excitability in migraine, i.e. a punctual normal measure of the cortical activation threshold for PT and a dynamic response pattern to repeated stimuli for VEP habituation. © International Headache Society 2015.
Disciplines :
Neurology
Author, co-author :
Ambrosini, A.;  IRCCS Neuromed, Headache Unit, via Atinense, 18, Pozzilli (Isernia), Italy
Iezzi, E.;  IRCCS Neuromed, Clinical Neurophysiology Unit, Italy
Perrotta, A.;  IRCCS Neuromed, Headache Unit, via Atinense, 18, Pozzilli (Isernia), Italy
Kisialiou, A.;  IRCCS San Raffaele Pisana, Unit of Clinical and Molecular Epidemiology, Italy
Nardella, A.;  IRCCS Neuromed, Clinical Neurophysiology Unit, Italy
Berardelli, A.;  IRCCS Neuromed, Clinical Neurophysiology Unit, Italy, Sapienza University of Rome, Department of Neurology and Psychiatry, Italy
Pierelli, F.;  IRCCS Neuromed, Headache Unit, via Atinense, 18, Pozzilli (Isernia), Italy, Sapienza University of Rome, Department of Medical-Surgical Sciences and Biotechnologies, Italy
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Correlation between habituation of visual-evoked potentials and magnetophosphene thresholds in migraine: A case-control study
Publication date :
2016
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
SAGE Publications Ltd
Volume :
36
Issue :
3
Pages :
258-264
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 November 2017

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