Comparison of chlordecone and NDL-PCB decontamination dynamics in growing male kids after cessation of oral exposure: Is there a potential to decrease the body levels of these pollutants by dietary supplementation of activated carbon or paraffin oil?
[en] Sixteen weaned male Alpine kids (Capra hircus) were subjected to a 21-day oral daily exposure of
0.05 mg kg 1 BW. d 1 of chlordecone (CLD) and 0.30 mg kg 1 BW. d 1 of each non-dioxin-like polychlorinated
biphenyls (NDL-PCBs, congeners 28, 52, 101, 138, 153 and 180). Four kids, identified as the
CONTA group, were slaughtered at the end of the exposure, while the remaining animals (n ¼ 12) were
fed with specific diets for an additional 21-day decontamination period before slaughtering. Kids from
the DECONTA (n ¼ 4) group were fed a control diet, while those from the AC10% and PO8% group
received pellets supplemented with 10% activated carbon (AC) and 8% paraffin oil (PO), respectively. CLD
and NDL-PCB levels in blood, liver, peri-renal fat and muscles from different groups were analysed to
compare the decontamination dynamics of the pollutants and to determine the efficiency of AC and PO to
decrease the body levels of pollutants.
After the decontamination period, the CLD levels considerably decreased (more than 60%) in blood,
liver, muscles and fat. Concerning NDL-PCBs, the decontamination process was much lower. Overall, CLD
appeared to be less retained in kids’ organism compared with NDL-PCBs, and the decontamination
dynamics of these pollutants appeared to be different because of their specific physicochemical properties
and lipophilicity. Furthermore, the dietary supplementation with AC or PO did not significantly
affect the decontamination dynamics.
Disciplines :
Environmental sciences & ecology
Author, co-author :
Lastel, Marie-Laure; Université de Lorraine > INRA > AFPA
Fournier, Agnès; Université de Lorraine > INRA > AFPA
Jurjanz, Stefan; Université de Lorraine > INRA > AFPA
Thomé, Jean-Pierre ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Joaquim-Justo, Célia ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Archimède, Harry; INRA > URZ
Mahieu, Maurice; INRA > URZ
Feidt, Cyril; Université de Lorraine > INRA > AFPA
Rychen, Guido; Université de Lorraine > INRA > AFPA
Language :
English
Title :
Comparison of chlordecone and NDL-PCB decontamination dynamics in growing male kids after cessation of oral exposure: Is there a potential to decrease the body levels of these pollutants by dietary supplementation of activated carbon or paraffin oil?
Commission Regulation (EC) n° 839/2008, Commission Regulation (EC) n° 839/2008 of 31 July 2008 amending Regulation (EC) n° 396/2005 of the European Parliament and of the Council as regards Annexes II, III and IV on maximum residue levels of pesticides in or on certain products. Off. J. Eur. Union L234 (2008), 1–216.
Commission Regulation (EC) n° 1259/2011, Commission Regulation (EC) n° 1259/2011 of 2 December 2011 amending Regulation (EC) n° 1881/2006 as regards maximum levels for dioxins, dioxin-like PCBs and non dioxin-like PCBs in foodstuffs. Off. J. Eur. Union L320 (2011), 18–23.
Becker, M.M., Gamble, W., Determination of the binding of 2, 4, 5, 2’, 4’, 5'-hexachlorobiphenyl by low density lipoprotein and bovine serum albumin. J. Toxicol. Envl. Heal. A Curr. Issues 9:2 (1982), 225–234.
Blanke, R.V., Fariss, M.W., Guzelian, P.S., Paterson, A., Smith, D.E., Identification of a reduced form of chlordecone (kepone®) in human stool. B Environ. Contam. Tox 20:1 (1978), 782–785.
Bordet, F., Thieffinne, A., Mallet, J., Heraud, F., Blateau, A., Inthavong, D., In-house validation for analytical methods and quality control for risk evaluation of chlordecone in food. Int. J. Environ. Anal. Chem. 87:13–14 (2007), 985–998.
Bourez, S., Le Lay, S., Van den Daelen, C., Louis, C., Larondelle, Y., Thomé, J.P., Schneider, Y.J., Dugail, I., Debier, C., Accumulation of polychlorinated biphenyls in adipocytes: selective targeting to lipid droplets and role of caveolin-1. PloS one, 7(2), 2012, e31834.
Bourez, S., Joly, A., Covaci, A., Remacle, C., Larondelle, Y., Schneider, Y.J., Debier, C., Accumulation capacity of primary cultures of adipocytes for PCB-126: influence of cell differentiation stage and triglyceride levels. Toxicol. Lett. 214:3 (2012), 243–250.
Bouveret, C., Rychen, G., Lerch, S., Jondreville, C., Feidt, C., Relative bioavailability of tropical volcanic soil-bound chlordecone in piglets. J. Agric. Food Chem. 61:38 (2013), 9269–9274.
Boylan, J.J., Egle, J.L., Guzelian, P.S., Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning. Science 199:4331 (1978), 893–895.
Boylan, J.J., Cohn, W.J., Egle, J.L., Blanke, R.V., Guzelian, P.S., Excretion of chlordecone by the gastrointestinal tract: evidence for a nonbiliary mechanism. Clin. Pharmacol. Ther. 25:5part1 (1979), 579–585.
Braund, D., Langlois, B., Conner, D., Moore, E., Feeding phenobarbital and activated carbon to accelerate dieldrin residue removal in a contaminated dairy herd. J. Dairy Sci. 54:3 (1971), 435–438.
Bungay, P.M., Dedrick, R.L., Matthews, H.B., Enteric transport of chlordecone (Kepone®) in the rat. J. Pharmacokinet. Biop 9:3 (1981), 309–341.
Chamberland, G., Tremblay, A., Lamothe, P., Gignac, M., Clinical chemistry, growth and PCB levels in beef cattle exposed to a PCB fire. Toxicol. Environ. Chem. 44:3–4 (1994), 177–187.
Cohn, W.J., Boylan, J.J., Blanke, R.V., Fariss, M.W., Howell, J.R., Guzelian, P.S., Treatment of chlordecone (Kepone) toxicity with cholestyramine: results of a controlled clinical trial. New Engl. J. Med. 298:5 (1978), 243–248.
Cook, R., Wilson, K., Removal of pesticide residues from dairy cattle. J. Dairy Sci. 54:5 (1971), 712–718.
Crookshank, H.R., Smalley, H.E., Radeleff, R.D., Effect of prolonged oral administration of activated charcoal and of ronnel on the well-being of sheep. J. Anim. Sci. 34:2 (1972), 322–325.
Debier, C., Pomeroy, P.P., Dupont, C., Joiris, C., Comblin, V., Le Boulengé, E., et al. Quantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals halichoerus grypus. Mar. Ecol. Prog. Ser. 247 (2003), 237–248.
Delannoy, M., Rychen, G., Fournier, A., Jondreville, C., Feidt, C., Effects of condensed organic matter on PCBs bioavailability in juvenile swine, an animal model for young children. Chemosphere 104 (2014), 105–112.
EPA, Toxicological Review of Chlordecone (Kepone) (CAS No. 143-50-0). In Support of Summary Information on the Integrated Risk Information System (IRIS). 2009 (Washington, DC).
Fariss, M.W., Blanke, R.V., Saady, J.J., Guzelian, P.S., Demonstration of major metabolic pathways for chlordecone (kepone) in humans. Drug Metab Dispos. Biol. Fate Chem. 8:6 (1980), 434–438.
Folch, J., Lees, M., Sloane-Stanley, G.H., A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:1 (1957), 497–509.
Foster, T., Morley, H., Purkayastha, R., Greenhalgh, R., Hunt, J., Residues in eggs and tissues of hens fed a ration containing low levels of pesticides with and without charcoal. J. Econ. Entomol. 65:4 (1972), 982–988.
Fournier, A., Rychen, G., Marchand, P., Toussaint, H., Le Bizec, B., Feidt, C., Polychlorinated biphenyl (PCB) decontamination kinetics in lactating goats (Capra hircus) following a contaminated corn silage exposure. J. Agric. Food Chem. 61:29 (2013), 7156–7164.
Fournier, A., Feidt, C., Lastel, M.-L., Archimede, H., Thome, J.-P., Mahieu, M., Rychen, G., Toxicokinetics of chlordecone in goats: implications for risk management in French West Indies. Chemosphere 171 (2017), 564–570.
Fries, G., Marrow, G. Jr., Gordon, C., Dryden, L., Hartman, A., Effect of activated carbon on elimination of organochlorine pesticides from rats and cows. J. Dairy Sci. 53:11 (1970), 1632–1637.
Fries, G.F., Marrow, G.S. Jr., Gordon, C.H., Long-term studies of residue retention and excretion by cows fed a polychlorinated biphenyl (Aroclor 1254). J. Agric. Food Chem. 21:1 (1973), 117–121.
Gill, I.J., Roberts, G.S., Galvin, J.W., Management of land and livestock contaminated with polychlorinated biphenyls. Aust. Vet. J. 69:7 (1992), 155–158.
Glynn, A., Aune, M., Nilsson, I., Darnerud, P.O., Ankarberg, E.H., Bignert, A., Nordlander, I., Declining levels of PCB, HCB and p, p′-DDE in adipose tissue from food producing bovines and swine in Sweden 1991–2004. Chemosphere 74:11 (2009), 1457–1462.
Guzelian, P.S., Comparative toxicology of chlordecone (Kepone) in humans and experimental animals. Annu. Rev. Pharmacol. Toxicol. 22:1 (1982), 89–113.
Ikegami, S., Umegaki, K., Kawashima, Y., Ichikawa, T., Viscous indigestible polysaccharides reduce accumulation of pentachlorobenzene in rats. J. Nutr., 124(5), 1994, 754.
INRA, Edition Quae Alimentation des bovins, ovins et caprins. Tables Inra, vol. 2007, 2007, 1–307.
IPCS, Environmental Health Criteria 43 (EHC 43): Chlordecone International Programme on Chemical Safety. United Nations Environment Programme. 1984, International Labour Organisation. World Health Organization.
IPCS, Environmental Health Criteria 140 (EHC 140): Polychlorinated Biphenyls and Terphenyls (Second Edition) International Programme on Chemical Safety. United Nations Environment Programme. 1993, International Labour Organisation. World Health Organization.
Jandacek, R.J., Tso, P., Factors affecting the storage and excretion of toxic lipophilic xenobiotics. Lipids 36:12 (2001), 1289–1305.
Jondreville, C., Bouveret, C., Lesueur-Jannoyer, M., Rychen, G., Feidt, C., Relative bioavailability of tropical volcanic soil-bound chlordecone in laying hens (gallus domesticus). Environ. Sci. Pollut. R. 20:1 (2012), 292–299.
Jondreville, C., Fournier, A., Mahieu, M., Feidt, C., Archimède, H., Rychen, G., Kinetic study of chlordecone orally given to laying hens (Gallus domesticus). Chemosphere 114 (2014), 275–281.
Jondreville, C., Lavigne, A., Jurjanz, S., Dalibard, C., Liabeuf, J.M., Clostre, F., Lesueur-Jannoyer, M., Contamination of free-range ducks by chlordecone in Martinique (French West Indies): a field study. Sci. Total Environ. 493 (2014), 336–341.
Lastel, M.L., Lerch, S., Fournier, A., Jurjanz, S., Mahieu, M., Archimède, H., Rychen, G., Chlordecone disappearance in tissues of growing goats after a one month decontamination period—effect of body fatness on chlordecone retention. Environ. Sci. Pollut. R. 23:4 (2016), 3176–3183.
Molowa, D.T., Shayne, A.G., Guzelian, P.S., Purification and characterization of chlordecone reductase from human liver. J. Biol. Chem. 261:27 (1986), 12624–12627.
Morgan, D.P., Dotson, T.B., Lin, L.I., Effectiveness of activated charcoal, mineral oil, and castor oil in limiting gastrointestinal absorption of a chlorinated hydrocarbon pesticide. Clin. Toxicol. 11:1 (1977), 61–70.
Multigner, L., Ndong, J.R., Giusti, A., Romana, M., Delacroix-Maillard, H., Cordier, S., Jégou, B., Thome, J.-P., Blanchet, P., Chlordecone exposure and risk of prostate cancer. J. Clin. Oncol. 28:21 (2010), 3457–3462.
Richter, E., Lay, J.P., Klein, W., Korte, F., Paraffin-stimulated excretion of 2, 4, 6, 2′, 4′-pentachlorobi [14 C] phenyl by rats. Toxicol. Appl. Pharm. 50:1 (1979), 17–23.
Rozman, K., Rozman, T., Greim, H., Enhanced fecal elimination of stored hexachlorobenzene from rats and rhesus monkeys by hexadecane or mineral oil. Toxicology 22:1 (1981), 33–44.
Rozman, K., Rozman, T., Greim, H., Nieman, I.J., Smith, G.S., Use of aliphatic hydrocarbons in feed to decrease body burdens of lipophilic toxicants in livestock. J. Agric. Food Chem. 30:1 (1982), 98–100.
Rozman, K., Rozman, T., Greim, H., Stimulation of nonbiliary, intestinal excretion of hexachlorobenzene in rhesus monkeys by mineral oil. Toxicol. Appl. Pharm. 70:2 (1983), 255–261.
Rozman, K., Rozman, T., Smith, G.S., Liquid paraffins in feed enhance fecal excretion of mirex and DDE from body stores of lactating goats and cows. B. Environ. Contam. Tox 32:1 (1984), 27–36.
Rychen, G., Jurjanz, S., Fournier, A., Toussaint, H., Feidt, C., Exposure of ruminants to persistent organic pollutants and potential of decontamination. Environ. Sci. Pollut. Res. 21:10 (2014), 6440–6447.
Scheufler, E., Rozman, K., Effect of hexadecane on the pharmacokinetics of hexachlorobenzene. Toxicol. Appl. Pharm. 75:2 (1984), 190–197.
Smith, J.C., Arant, F.S., Residues of kepone in milk from cows receiving treated Feed1. J. Econ. Entomol. 60:4 (1967), 925–927.
Soine, P.J., Blanke, R.V., Guzelian, P.S., Schwartz, C.C., Preferential binding of chlordecone to the protein and high density lipoprotein fractions of plasma from humans and other species. J. Toxicol. Env. Health 9:1 (1982), 107–118.
Soine, P.J., Blanke, R.V., Schwartz, C.C., Chlordecone metabolism in the pig. Toxicol. Lett. 17:1–2 (1983), 35–41.
Soine, P.J., Blanke, R.V., Schwartz, C.C., Isolation of chlordecone binding proteins from pig liver cytosol. J. Toxicol. Env. Health 14:2–3 (1984), 305–317.
Spindler-Vomachka, M., Vodicnik, M.J., Lech, J.J., Transport of 2, 4, 5, 2′, 4′, 5′-hexachlorobiphenyl by lipoproteins in vivo. Toxicol. Appl. Pharm. 74:1 (1984), 70–77.
Sweetman, A.J., Thomas, G.O., Jones, K.C., Modelling the fate and behaviour of lipophilic organic contaminants in lactating dairy cows. Environ. Pollut. 104:2 (1999), 261–270.
Thomas, G.O., Sweetman, A.J., Jones, K.C., Metabolism and body-burden of PCBs in lactating dairy cows. Chemosphere 39:9 (1999), 1533–1544.
Tonnelier, A., Coecke, S., Zaldívar, J.M., Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model. Arch. Toxicol. 86:3 (2012), 393–403.
Wilson, K.A., Cook, R.M., Metabolism of xenobiotics in ruminants. Use of activated carbon as an antidote for pesticide poisoning in ruminants. J. Agric. Food Chem. 18:3 (1970), 437–440.
