ORBi: Braquenier Jean-Baptiste - Anxiety in adult female mice following perinatal exposure to chlorpyrifos.

Reference : Anxiety in adult female mice following perinatal exposure to chlorpyrifos.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Environmental sciences & ecology
	To cite this reference:	http://hdl.handle.net/2268/21499

Title :	Anxiety in adult female mice following perinatal exposure to chlorpyrifos.
Language :	English
Author, co-author :	Braquenier, Jean-Baptiste [Université de Liège - ULG > Département des sciences et gestion de l'environnement > Ecophysiologie et physiologie animale > >]
	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
	Tirelli, Ezio [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
	Plumier, Jean-Christophe [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Ecophysiologie et physiologie animale >]
Publication date :	2010
Journal title :	Neurotoxicology & Teratology
Publisher :	Pergamon Press
Volume :	32
Pages :	234-239
Audience :	International
ISSN :	0892-0362
e-ISSN :	1872-9738
City :	New York
Country :	NY
Keywords :	[en] Behavior ; cholinesterase ; mood
Abstract :	[en] Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific perinatal periods decreased anxiety-like behaviors. In the present study, we report that chronic perinatal exposure (GD15-PND14) to low doses of CPF leads to an increase (and not a decrease) in anxiety-like behaviors of female mouse offspring. Pregnant or lactating female mice were exposed to CPF (0.2; 1; or 5 mg/kg day) by oral treatment during 18 consecutive days. Following a recovery period of several weeks, the anxiety of adult female offspring was determined using neurobehavioral tests (elevated plus-maze and light/dark box tests). Our results showed that CPF-exposed female offspring were more anxious than controls. In addition, the magnitude of anxiety profile alterations depended on the level of exposure to CPF during gestation and lactation with a maximal effect observed at the 1 mg/kg day dose. Our results confirm that OP exposure during the perinatal period can induce long-term alterations in mouse anxiety-like behaviors and suggest that the routes of administration and the duration of OP exposure during brain development may be factors to consider when studying the development of anxiety.
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/21499
DOI :	10.1016/j.ntt.2009.08.008

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