Reference : Anxiety in adult female mice following perinatal exposure to chlorpyrifos.
Scientific journals : Article
Life sciences : Environmental sciences & ecology
http://hdl.handle.net/2268/21499
Anxiety in adult female mice following perinatal exposure to chlorpyrifos.
English
Braquenier, Jean-Baptiste [Université de Liège - ULG > Département des sciences et gestion de l'environnement > Ecophysiologie et physiologie animale > >]
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Plumier, Jean-Christophe mailto [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Ecophysiologie et physiologie animale >]
2010
Neurotoxicology & Teratology
Pergamon Press
32
234-239
Yes (verified by ORBi)
International
0892-0362
1872-9738
New York
NY
[en] Behavior ; cholinesterase ; mood
[en] Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific perinatal periods decreased anxiety-like behaviors. In the present study, we report that chronic perinatal exposure (GD15-PND14) to low doses of CPF leads to an increase (and not a decrease) in anxiety-like behaviors of female mouse offspring. Pregnant or lactating female mice were exposed to CPF (0.2; 1; or 5 mg/kg day) by oral treatment during 18 consecutive days. Following a recovery period of several weeks, the anxiety of adult female offspring was determined using neurobehavioral tests (elevated plus-maze and light/dark box tests). Our results showed that CPF-exposed female offspring were more anxious than controls. In addition, the magnitude of anxiety profile alterations depended on the level of exposure to CPF during gestation and lactation with a maximal effect observed at the 1 mg/kg day dose. Our results confirm that OP exposure during the perinatal period can induce long-term alterations in mouse anxiety-like behaviors and suggest that the routes of administration and the duration of OP exposure during brain development may be factors to consider when studying the development of anxiety.
Researchers
http://hdl.handle.net/2268/21499
10.1016/j.ntt.2009.08.008

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