Reference : Multifaceted Brain Networks Reconfiguration in Disorders of Consciousness Uncovered b...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/214988
Multifaceted Brain Networks Reconfiguration in Disorders of Consciousness Uncovered by Co-Activation Patterns
English
Di Perri, Carol* mailto [Université de Liège - ULiege > > GIGA : Coma Group >]
Amico, Enrico* mailto [> >]
Heine, Lizette mailto [Université de Liège - ULiege > > Centre de recherches du cyclotron >]
Annen, Jitka mailto [Université de Liège - ULiege > > Centre de recherches du cyclotron >]
Martial, Charlotte mailto [Université de Liège - ULiege > > GIGA : Coma Group >]
Larroque, Stephen Karl mailto [Université de Liège - ULiège > > > GIGA - MASSGPFS]
Soddu, Andrea mailto [Université de Liège - ULiege > > Centre de recherches du cyclotron >]
Marinazzo, Daniele [University of Ghent, Ghent, Belgium > Department of Data-analysis > > >]
LAUREYS, Steven mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie >]
* These authors have contributed equally to this work.
In press
Human Brain Mapping
Wiley Liss
Yes (verified by ORBi)
International
1065-9471
1097-0193
New York
NY
[en] pathological hyperconnectivity ; dynamic network interactions ; co-activation patterns ; unresponsive wakefulness syndrome
[en] Introduction: Given that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network’s (DMN) connectivity in patients with disorders of consciousness. Methods: Resting-state fMRI volumes of a convenience sample of 17 patients in unresponsive wakefulness syndrome (UWS) and controls were reduced to a spatiotemporal point process by selecting critical time points in the posterior cingulate cortex (PCC). Spatial clustering was performed on the extracted PCC time frames to obtain 8 different co-activation patterns (CAPs). We investigated spatial connectivity patterns positively and negatively correlated with PCC using both CAPs and standard stationary method. We calculated CAPs occurrences and the total number of frames. Results: Compared to controls, patients showed (i) decreased within-network positive correlations and between-network negative correlations, (ii) emergence of “pathological” within-network negative correlations and between-network positive correlations (better defined with CAPs), and (iii) “pathological” increases in within-network positive correlations and between-network negative correlations (only detectable using CAPs). Patients showed decreased occurrence of DMN-like CAPs (1–2) compared to controls. No between-group differences were observed in the total number of frames Conclusion: CAPs reveal at a more fine-grained level the multifaceted spatial connectivity reconfiguration following the DMN disruption in UWS patients, which is more complex than previously thought and suggests alternative anatomical substrates for consciousness. BOLD fluctuations do not seem to differ between patients and controls, suggesting that BOLD response represents an intrinsic feature of the signal, and therefore that spatial configuration is more important for consciousness than BOLD activation itself.
GIGA-Consciousness
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Luminous ; Commission européenne : Direction générale de la Recherche ; Center-TBI ; Human Brain Project (HBP) ; James McDonnell Foundation ; Agence spatiale européenne - ESA ; Belspo ; Fondazione Europea di Ricerca Biomedica ; BIAL Foundation ; Wallonia-Brussels Federation Concerted Research Action ; Mind Science Foundation
http://hdl.handle.net/2268/214988
10.1002/hbm.23826

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