Reference : Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Ant...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/21496
Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke.
English
Blondeau, Nicolas [Université de Nice Sophia Antipolis > Institut de Pharmacologie Moléculaires et Cellulaires > > >]
Nguemeni, C. [> Institut de Pharmacologie Moléculaires et Cellulaires > > >]
Debruyne, D. N. [> Institut de Pharmacologie Moléculaires et Cellulaires > > >]
Piens, M. [Université de Liège - ULG > Sciences et Gestion de l'Environnement > Physiologie Animale > >]
Wu, X. [Uniformed Sevices University of the Health Sciences > Department of Neurology and Neuroscience program > > >]
Pan, H. [Uniformed Sevices University of the Health Sciences > Department of Neurology and Neuroscience program > > >]
Hu, X. [Uniformed Sevices University of the Health Sciences > Department of Neurology and Neuroscience program > > >]
Gandin, C. [Institut de Pharmacologie Moléculaires et Cellulaires > > > >]
Lipsky, R. H. [George Mason University > Krasnow Institute for Advanced Study > > >]
Plumier, Jean-Christophe mailto [Université de Liège - ULg > Département des sciences et gestion de l'environnement > Ecophysiologie et physiologie animale >]
Marini, A. M. [Uniformed Sevices University of the Health Sciences > Department of Neurology and Neuroscience program > > >]
Heurteaux, Catherine [université de Nice Sophia Antipolis > Institut de Pharmacologie Moléculaires et Cellulaires > > >]
2009
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Nature publishing
Yes (verified by ORBi)
International
0893-133X
1470-634X
London
United Kingdom
[en] stroke ; neurogenesis ; antidepressant effects
[en] Omega-3 polyunsaturated fatty acids are known to have therapeutic potential in several neurological and psychiatric disorders. However, the molecular mechanisms of action underlying these effects are not well elucidated. We previously showed that alpha-linolenic acid (ALA) reduced ischemic brain damage after a single treatment. To follow-up this finding, we investigated whether subchronic ALA treatment promoted neuronal plasticity. Three sequential injections with a neuroprotective dose of ALA increased neurogenesis and expression of key proteins involved in synaptic functions, namely, synaptophysin-1, VAMP-2, and SNAP-25, as well as proteins supporting glutamatergic neurotransmission, namely, V-GLUT1 and V-GLUT2. These effects were correlated with an increase in brain-derived neurotrophic factor (BDNF) protein levels, both in vitro using neural stem cells and hippocampal cultures and in vivo, after subchronic ALA treatment. Given that BDNF has antidepressant activity, this led us to test whether subchronic ALA treatment could produce antidepressant-like behavior. ALA-treated mice had significantly reduced measures of depressive-like behavior compared with vehicle-treated animals, suggesting another aspect of ALA treatment that could stimulate functional stroke recovery by potentially combining acute neuroprotection with long-term repair/compensatory plasticity. Indeed, three sequential injections of ALA enhanced protection, either as a pretreatment, wherein it reduced post-ischemic infarct volume 24 h after a 1-hour occlusion of the middle cerebral artery or as post-treatment therapy, wherein it augmented animal survival rates by threefold 10 days after ischemia.Neuropsychopharmacology advance online publication, 29 July 2009; doi:10.1038/npp.2009.84.
http://hdl.handle.net/2268/21496
10.1038/npp.2009.84

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