Reference : Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/214217
Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.
English
Bahri, Mohamed Ali mailto [Université de Liège > Centre de recherches du cyclotron > Centre de recherches du cyclotron > >]
Plenevaux, Alain mailto [Université de Liège > Département de chimie (sciences) > Département de chimie (sciences) >]
Aerts, Joël [Université de Liège > Département de pharmacie > Département de pharmacie >]
Bastin, Christine mailto [Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Becker, Guillaume mailto [Université de Liège > > Centre de recherches du cyclotron >]
Mercier, Joël []
Valade, Anne []
Buchanan, Tim []
Mestdagh, Nathalie []
LEDOUX, Didier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs généraux >]
Seret, Alain mailto [Université de Liège > Département de physique > Imagerie médicale expérimentale >]
Luxen, André mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
Salmon, Eric mailto [Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Nov-2017
Alzheimer’s & Dementia: Translational Research & Clinical Interventions
4
4
481-486
Yes
International
2352-8737
[en] sv2a ; neuroimaging ; synapse density ; fluorine-18 ; PET ; Alzheimer’s disease
[en] Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET).
Methods: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume.
Results: [18F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship.
Discussion: The cerebral distribution of [18F]UCB-H is similar to that recently observed with carbon-11 UCB-J ([11C]UCB-J). An accurate [18F]UCB-H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied in vivo in normal and pathological aging.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/214217
10.1016/j.trci.2017.08.004
http://www.sciencedirect.com/science/article/pii/S2352873717300501

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