Article (Scientific journals)
Combinaison gliptine-gliflozine dans le traitement du diabete de type 2.
Scheen, André; Paquot, Nicolas
2016In Revue Médicale Suisse, 12 (527), p. 1384-1388
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Abstract :
[en] Type 2 diabetes (T2D) is a complex disease with multiple defects, which generally require a combination of several pharmacological approaches to control hyperglycaemia. Combining a dipeptidyl peptidase-4 inhibitor (DPP-4i) and a sodium-glucose cotransporter type 2 inhibitor (SGT2i) appears to be an attractive approach because the two drugs exert different and potentially complementary glucose-lowering effects. Dual therapy (initial combination or stepwise approach) is more potent than either monotherapy in patients treated with diet and exercise or already treated with metformin. Combining the two pharmacological options is safe and does not induce hypoglycaemia. Two fixed-dose combinations (FDCs) are already available (saxagliptin-dapagliflozin and linagliptin-empagliflozin) and others are in current development.
Disciplines :
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Paquot, Nicolas ;  Université de Liège > Département des sciences de la santé publique > Diabétologie, nutrition et maladies métaboliques
Language :
French
Title :
Combinaison gliptine-gliflozine dans le traitement du diabete de type 2.
Alternative titles :
[en] Gliptin-gliflozin combination for treating type 2 diabetes
Publication date :
2016
Journal title :
Revue Médicale Suisse
ISSN :
1660-9379
Publisher :
Medecine et Hygiène, Switzerland
Volume :
12
Issue :
527
Pages :
1384-1388
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 September 2017

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