Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour
[en] positively correlated with floating behavior on the third test. A twoweek-
long pretreatment regime with imipramine (7.5 mg/kg/day) or thiamine (200 mg/kg/day),
which is known to have antidepressant properties, reduced the GSK3β over-expression and
decreased floating behavior on Day 5. GSK3α mRNA levels were measured in the hippocampus
and prefrontal cortex on Days 1, 2 and 5. GSK3α expression was decreased in the prefrontal
cortex on Day 2 and increased on Day 5. In this model, GSK3α mRNA changes were prevented
by imipramine or thiamine treatment. There was a significant correlation between the expression
of the two isoforms in the prefrontal cortex on Day 2 in untreated group. These results provide
the first evidence for the potential involvement of GSK3α in depressive-like behaviours and as a
target of anti-depressant therapy. Furthermore, the correlations suggest some cross-talk may exist
between the two GSK3 isoforms.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Pavlov, Dmitrii; Sechenov First Moscow State Medical University,
Markova, Nataliia; Sechenov First Moscow State Medical University,
Bettendorff, Lucien ; Université de Liège > GIGA-Neurosciences > Laboratory of Neurophysiology
Chekhonin, Vladimir
Pomytkin, Igor
Lioudyno, Victoria
Svistunov, Andrei
Ponomarev, Eugene
Lesch, Klaus-Peter
Strekalova, Tatyana; Maastricht University > Department of Neuroscience
Language :
English
Title :
Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour
Publication date :
2017
Journal title :
Behavioural Brain Research
ISSN :
0166-4328
eISSN :
1872-7549
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
335
Pages :
122-127
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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