Article (Scientific journals)
NO-ergic mechanisms are implicated in a disturbed cardiac rhythm after systemic application of lipopolysaccharide E. coli to rats
Koulchitsky, Stanislav; Subbotin, O. V.; Azev, O. A. et al.
2002In Autonomic Neuroscience: Basic and Clinical, 98 (1-2), p. 99-101
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Keywords :
Endotoxin; Nitric oxide; Heart arrhythmia; heart; lipopolysaccharide
Abstract :
[en] In acute experiments on nembutal-urethan-anaesthetized rats, a slow infusion of subseptic dose of lipopolysaccharide (LPS) Escherichia coli (1 mg/ml) via the right jugular vein immediately led to bradycardia and extrasystoles. Preliminary administration of 20 mg/kg N(G)-nitro-L-arginine methyl ester (L-NAME) or 30 mg/kg aminoguanidine hydrochloride prevented the LPS-induced extrasystoles but did not affect the pattern of bradycardia. We conclude that nitric oxide (NO)-ergic mechanisms are involved in provoking electrical instability of the heart in conditions of endotoxemia.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Koulchitsky, Stanislav ;  Université de Liège > Département des sciences biomédicales et précliniques > Pharmacologie
Subbotin, O. V.
Azev, O. A.
Kulchitsky, V. A.
Language :
English
Title :
NO-ergic mechanisms are implicated in a disturbed cardiac rhythm after systemic application of lipopolysaccharide E. coli to rats
Publication date :
2002
Journal title :
Autonomic Neuroscience: Basic and Clinical
ISSN :
1566-0702
eISSN :
1872-7484
Publisher :
Elsevier Science
Volume :
98
Issue :
1-2
Pages :
99-101
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 August 2017

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